ArticleBritish journal of cancer2011
HPV testing as a triage for borderline or mild dyskaryosis on cervical cytology: results from the Sentinel Sites study.
Article in British journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immediate referral to colposcopy versus cytological surveillance for minor cervical cytological abnormalities in the absence of HPV test.The Cochrane database of systematic reviews · 2017Pooled it
- Effectiveness of Visual Inspection and Liquid-Based Cytology in Screening Asymptomatic Women for Cervical Neoplasia.Journal of pharmacy & bioallied sciences · 2025Article
- Empowering the on-site detection of nucleic acids by integrating CRISPR and digital signal processing.Nature communications · 2024Article
- Supporting the implementation of new healthcare technologies by investigating generalisability of pilot studies using area-level statistics.BMC health services research · 2022Article
- Human papillomavirus genotype distribution in low-grade squamous intraepithelial lesion cytology, and its immediate risk for high-grade cervical lesion or cancer: a single-center, cross-sectional study.Obstetrics & gynecology science · 2022Article
- The use of biomarkers and HPV genotyping to improve diagnostic accuracy in women with a transformation zone type 3.British journal of cancer · 2022Article
- The use of biomarkers and HPV genotyping to improve diagnostic accuracy in women with a transformation zone type 3.British journal of cancer · 2022Article
- The artificial intelligence-assisted cytology diagnostic system in large-scale cervical cancer screening: A population-based cohort study of 0.7 million women.Cancer medicine · 2020Article
- Combined dynamic spectral imaging and routine colposcopy strategy for the diagnosis of pre-cancerous cervical lesions.Experimental and therapeutic medicine · 2019Article
- Recognizing Gynecological Cancer in Primary Care: Risk Factors, Red Flags, and Referrals.Advances in therapy · 2018Article
- Article
- Molecular tests potentially improving HPV screening and genotyping for cervical cancer prevention.Expert review of molecular diagnostics · 2017Review
- Clinical and analytical performance of the BD Onclarity™ HPV assay for detection of CIN2+ lesions on SurePath samples.Papillomavirus research (Amsterdam, Netherlands) · 2016Article
- Triage of HPV positive women in cervical cancer screening.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Review
- Management of borderline change in endocervical cells: a more dependable approach.British journal of cancer · 2014Article
- Knowledge of human papillomavirus (HPV) testing in the USA, the UK and Australia: an international survey.Sexually transmitted infections · 2014Article
- Triaging borderline/mild dyskaryotic Pap cytology with p16/Ki-67 dual-stained cytology testing: cross-sectional and longitudinal outcome study.British journal of cancer · 2014Article
- Cost effectiveness of human papillomavirus test of cure after treatment for cervical intraepithelial neoplasia in England: economic analysis from NHS Sentinel Sites Study.BMJ (Clinical research ed.) · 2012Article
- Cost and logistics of alternative roll-out options for implementing human papillomavirus testing as a triage in cervical screening: results of the sentinel sites study.British journal of cancer · 2012Article
- Cytology and human papillomavirus testing 6 to 12 months after ASCUS or LSIL cytology in organized screening to predict high-grade cervical neoplasia between screening rounds.Journal of clinical microbiology · 2012Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarlier pilot studies of human papillomavirus (HPV) triage concluded that HPV triage was feasible and cost-effective. The aim of the present study was to study the impact of wider rollout of HPV triage for women with low-grade cytology on colposcopy referral and outcomes.
methodsHuman papillomavirus testing of liquid-based cytology (LBC) samples showing low-grade abnormalities was used to select women for colposcopy referral at six sites in England. Samples from 10,051 women aged 25-64 years with routine call or recall cytology reported as borderline or mild dyskaryosis were included.
resultsHuman papillomavirus-positive rates were 53.7% in women with borderline cytology and 83.9% in those with mild dyskaryosis. The range between sites was 34.8-73.3% for borderline cytology, and 73.4-91.6% for mild dyskaryosis. In the single site using both LBC technologies there was no difference in rates between the two technologies. The positive predictive value of an HPV test was 16.3% for CIN2 or worse and 6.1% for CIN3 or worse, although there was considerable variation between sites.
conclusionTriaging women with borderline cytological abnormalities and mild dyskaryosis with HPV testing would allow approximately a third of these women to be returned immediately to routine recall, and for a substantial proportion to be referred for colposcopy without repeat cytology. Variation in HPV-positive rates results in differing colposcopy workload.
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