ArticlePharmacogenetics and genomics2011
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
Article in Pharmacogenetics and genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
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- Comparison of Growth Performance and Meat Quality Traits of Commercial Cross-Bred Pigs versus the Large Black Pig Breed.Animals : an open access journal from MDPI · 2021Article
- Genetic architecture of cardiometabolic risks in people living with HIV.BMC medicine · 2020Article
- Minding the gap in HIV host genetics: opportunities and challenges.Human genetics · 2020Review
- BMPR2 promotes fatty acid oxidation and protects white adipocytes from cell death in mice.Communications biology · 2020Article
- Host genetic variation and HIV disease: from mapping to mechanism.Immunogenetics · 2017Review
- Cord blood DNA methylation and adiposity measures in early and mid-childhood.Clinical epigenetics · 2017Article
- CNV Analysis Associates AKNAD1 with Type-2 Diabetes in Jordan Subpopulations.Scientific reports · 2015Article
- Comparative Analyses of QTLs Influencing Obesity and Metabolic Phenotypes in Pigs and Humans.PloS one · 2015Article
- Deleterious nonsynonymous single nucleotide polymorphisms in human solute carriers: the first comparison of three prediction methods.European journal of drug metabolism and pharmacokinetics · 2013Article
- A computational study identifies HIV progression-related genes using mRMR and shortest path tracing.PloS one · 2013Article
- Genomic copy number variants: evidence for association with antibody response to anthrax vaccine adsorbed.PloS one · 2013Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveGenetic studies may help explain abnormalities of fat distribution in HIV-infected patients treated with antiretroviral therapy (ARV).
methodsSubcutaneous adipose tissue (SAT) volume measured by MRI in the leg, the lower trunk, the upper trunk, and the arm was examined in 192 HIV-infected White men, ARV-treated from the Fat Redistribution and Metabolic Change in HIV infection study. Single-nucleotide polymorphisms were assayed using the Illumina Human CNV370-quad beadchip. Multivariate and univariate genome-wide association analyses of the four SAT depots were implemented in PLINK software adjusted for age and ARV duration. Functional annotation analysis using Ingenuity Systems Pathway Analysis tool was carried out for markers with P lower than 10(-3) near known genes identified by multivariate analysis.
resultsLoci (rs10504906, rs13267998, rs921231) in or near the anion exchanger solute carrier family 26, member 7 isoform a (SLC26A7) were strongly associated with the upper trunk and the arm SAT (9.8×10(-7) ≤P<7.8×10(-6)). Loci (rs193139, rs7523050, rs1761621) in and near a gene-rich region including G-protein-signaling modulator 2 (GPSM2) and syntaxin-binding protein 3 (STXBP3) were significantly associated with the lower body SAT depots (9.9×10(-7) ≤P<9.5×10(-6)). GPSM2 is associated with cell division and cancer whereas STXBP3 is associated with glucose metabolism in adipoctyes. Ingenuity Systems Pathway Analysis identified atherosclerosis, mitochondrial function, and T-cell-mediated apoptosis as processes related to SAT volume in HIV-infected individuals (P<5×10(-3)).
conclusionOur results are limited by the small sample size and replication is needed; however, this genomic scan uncovered new genes associated with metabolism and inflammatory pathways that may affect SAT volume in ARV-treated HIV-infected patients.
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