ArticleThe EMBO journal1990
A neuropeptide precursor in cerebellum: proenkephalin exists in subpopulations of both neurons and astrocytes.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 112 citations in OpenAlex.
- Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- Opioid Receptors in Immune and Glial Cells-Implications for Pain Control.Frontiers in immunology · 2020Review
- Sex differences in innate immunity and its impact on opioid pharmacology.Journal of neuroscience research · 2017Review
- Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System.Frontiers in pediatrics · 2017Review
- Prenatal morphine exposure reduces pyramidal neurons in CA1, CA2 and CA3 subfields of mice hippocampus.Iranian journal of basic medical sciences · 2014Article
- Interactions of HIV and drugs of abuse: the importance of glia, neural progenitors, and host genetic factors.International review of neurobiology · 2014Review
- Opiate drug use and the pathophysiology of neuroAIDS.Current HIV research · 2012Review
- Purkinje cells loss in off spring due to maternal morphine sulfate exposure: a morphometric study.Anatomy & cell biology · 2012Article
- Selective vulnerability of cerebellar granule neuroblasts and their progeny to drugs with abuse liability.Cerebellum (London, England) · 2003Review
- Neurotransmitters, neuropeptides and calcium binding proteins in developing human cerebellum: a review.The Histochemical journal · 2000Review
- Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation.The European journal of neuroscience · 2000Article
- Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Article
- kappa-opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids.Brain research · 1996Article
- mu-Opioid receptor-induced Ca2+ mobilization and astroglial development: morphine inhibits DNA synthesis and stimulates cellular hypertrophy through a Ca(2+)-dependent mechanism.Brain research · 1996Article
- Proenkephalin is a nuclear protein responsive to growth arrest and differentiation signals.The Journal of cell biology · 1995Article
- The transcriptional regulation of the preproenkephalin gene.The Biochemical journal · 1995Review
- Morphine inhibits Purkinje cell survival and dendritic differentiation in organotypic cultures of the mouse cerebellum.Experimental neurology · 1994Article
- Directed establishment of rat brain cell lines with the phenotypic characteristics of type 1 astrocytes.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Delta and kappa opiate receptors in primary astroglial cultures. Part II: Receptor sets in cultures from various brain regions and interactions with beta-receptor activated cyclic AMP.Neurochemical research · 1992Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adult rat cerebellum has minimal enkephalin immunoreactivity and is devoid of opiate-binding activity. Using novel monoclonal antibodies to the mammalian enkephalin precursor, we describe the immunofluorescent detection of proenkephalin, in the absence of mature enkephalin peptides, in subpopulations of rat cerebellar neurons and astrocytes. In cryostat sections, neurons that express proenkephalin include Golgi cells, macroneurons within deep cerebellar nuclei and a subpopulation of Purkinje cells. Proenkephalin messenger RNA and protein are present in subpopulations of both grey and white matter astrocytes, but not Bergmann glia. In dissociated glial culture, proenkephalin is expressed in process-bearing astrocytes, apparently in association with a subset of intermediate filaments. Proenkephalin within astrocytes is not seen until the second postnatal week and increases through to adulthood. Neuropeptide gene expression adds to the growing range of neuronal-type properties glial cells can display.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.