Trial reportThe American journal of tropical medicine and hygiene2011
Latrine promotion for trachoma: assessment of mortality from a cluster-randomized trial in Ethiopia.
Trial report in The American journal of tropical medicine and hygiene, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00322972 (Eliminating Trachoma With Repeat Mass Drug Treatment), which is not on this map. Cited by 13 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Eliminating Trachoma With Repeat Mass Drug Treatment
Who cites it
13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Impact on childhood mortality of interventions to improve drinking water, sanitation, and hygiene (WASH) to households: Systematic review and meta-analysis.PLoS medicine · 2023Pooled it
- Effect of Sanitation Interventions on Health Outcomes: A Systematic Review of Cluster-Randomized Controlled Trials in Rural Communities of Low- and Middle-Income Countries.International journal of environmental research and public health · 2021Pooled it
- Effectiveness of community and school-based sanitation interventions in improving latrine coverage: a systematic review and meta-analysis of randomized controlled interventions.Environmental health and preventive medicine · 2021Pooled it
- Antibiotics for trachoma.The Cochrane database of systematic reviews · 2019Pooled it
- Trachoma.BMJ clinical evidence · 2016Pooled it
- Mass drug administration trials of azithromycin: an analysis to inform future research and guidelines.Infectious diseases of poverty · 2025Review
- Interventions promoting uptake of water, sanitation and hygiene (WASH) technologies in low- and middle-income countries: An evidence and gap map of effectiveness studies.Campbell systematic reviews · 2021Article
- PROTOCOL: Water, sanitation and hygiene for reducing childhood mortality in low- and middle-income countries.Campbell systematic reviews · 2021Article
- Models of Trachoma Transmission and Their Policy Implications: From Control to Elimination.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Review
- Prevalence of trachoma in the Kayes region of Mali eight years after stopping mass drug administration.PLoS neglected tropical diseases · 2018Article
- Is Using a Latrine "A Strange Thing To Do"? A Mixed-Methods Study of Sanitation Preference and Behaviors in Rural Ethiopia.The American journal of tropical medicine and hygiene · 2017Article
- Antibiotic resistance as collateral damage: the tragedy of the commons in a two-disease setting.Mathematical biosciences · 2015Article
- Trachoma: an update on prevention, diagnosis, and treatment.Current opinion in ophthalmology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Trachoma control strategies, including latrine construction and antibiotic distribution, are directed at reducing ocular chlamydia, but may have additional benefits. In a cluster-randomized clinical trial, 24 subkebeles (administrative geographic units) in Ethiopia were offered a single mass azithromycin treatment, and half were randomized to receive an intensive latrine promotion. At a follow-up census 26 months after the baseline treatment, 320 persons had died. The mortality rate of children 1-5 years of age was 3.87 (95% confidence interval [CI] = 2.19-6.82) per 1,000 person-years in the latrine promotion arm, and 2.72 (95% CI = 1.37-5.42) per 1,000 person-years in the control arm. In a multi-level mixed effects logistic regression model controlling for age, there was no difference in mortality in persons randomized into the latrine or control arms (odds ratio = 1.18, 95% CI = 0.89-1.58). Latrine promotion provided no additional effect on mortality in the context of an azithromycin distribution program (clinicaltrials.gov, #NCT00322972).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.