ArticleProceedings of the National Academy of Sciences of the United States of America2011
Circadian transcriptional regulation by the posttranslational oscillator without de novo clock gene expression in Synechococcus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Environmental and molecular noise buffering by the cyanobacterial clock in individual cells.Nature communications · 2025Article
- Circadian regulation of metabolism across photosynthetic organisms.The Plant journal : for cell and molecular biology · 2023Review
- Circadian clock helps cyanobacteria manage energy in coastal and high latitude ocean.The ISME journal · 2020Article
- A Hard Day's Night: Cyanobacteria in Diel Cycles.Trends in microbiology · 2019Review
- High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival.PLoS genetics · 2018Article
- The primary transcriptome of the fast-growing cyanobacteriumBiotechnology for biofuels · 2018Article
- Article
- Redox crisis underlies conditional light-dark lethality in cyanobacterial mutants that lack the circadian regulator, RpaA.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The stringent response regulates adaptation to darkness in the cyanobacterium Synechococcus elongatus.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Cyanobacterial Ribosomal-Associated Protein LrtA Is Involved in Post-Stress Survival in Synechocystis sp. PCC 6803.PloS one · 2016Article
- Human Gut Bacteria Are Sensitive to Melatonin and Express Endogenous Circadian Rhythmicity.PloS one · 2016Article
- Article
- The circadian oscillator in Synechococcus elongatus controls metabolite partitioning during diurnal growth.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Changes in primary metabolism under light and dark conditions in response to overproduction of a response regulator RpaA in the unicellular cyanobacterium Synechocystis sp. PCC 6803.Frontiers in microbiology · 2015Article
- The cyanobacterial clock and metabolism.Current opinion in microbiology · 2014Review
- Hypersensitive photic responses and intact genome-wide transcriptional control without the KaiC phosphorylation cycle in the Synechococcus circadian system.Journal of bacteriology · 2014Article
- Metabolic compensation and circadian resilience in prokaryotic cyanobacteria.Annual review of biochemistry · 2014Review
- Article
- Attenuation of the posttranslational oscillator via transcription-translation feedback enhances circadian-phase shifts in Synechococcus.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Robust circadian oscillations in growing cyanobacteria require transcriptional feedback.Science (New York, N.Y.) · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian rhythms are a fundamental property of most organisms, from cyanobacteria to humans. In the unicellular obligately photoautotrophic cyanobacterium Synechococcus elongatus PCC 7942, essentially all promoter activities are controlled by the KaiABC-based clock under continuous light conditions. When Synechococcus cells are transferred from the light to continuous dark (DD) conditions, the expression of most genes, including the clock genes kaiA and kaiBC, is rapidly down-regulated, whereas the KaiC phosphorylation cycle persists. Therefore, we speculated that the posttranslational oscillator might not drive the transcriptional circadian output without de novo expression of the kai genes. Here we show that the cyanobacterial clock regulates the transcriptional output even in the dark. The expression of a subset of genes in the genomes of cells grown in the dark was dramatically affected by kaiABC nullification, and the magnitude of dark induction was dependent on the time at which the cells were transferred from the light to the dark. Moreover, under DD conditions, the expression of some dark-induced gene transcripts exhibited temperature-compensated damped oscillations, which were nullified in kaiABC-null strains and were affected by a kaiC period mutation. These results indicate that the Kai protein-based posttranslational oscillator can drive the circadian transcriptional output even without the de novo expression of the clock genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.