ArticleProceedings of the National Academy of Sciences of the United States of America2011
Misfolded human tRNA isodecoder binds and neutralizes a 3' UTR-embedded Alu element.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 41 citations in OpenAlex.
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- tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators.Biomolecules · 2024Review
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- Genome-wide interrogation of transfer RNA-derived small RNAs in a mouse model of traumatic brain injury.Neural regeneration research · 2022Article
- tRNA derived small RNAs-Small players with big roles.Frontiers in genetics · 2022Review
- On the Track of the Missing tRNA Genes: A Source of Non-Canonical Functions?Frontiers in molecular biosciences · 2021Review
- Noncanonical Roles of tRNAs: tRNA Fragments and Beyond.Annual review of genetics · 2020Review
- Hijacking tRNAs From Translation: Regulatory Functions of tRNAs in Mammalian Cell Physiology.Frontiers in molecular biosciences · 2020Review
- Differential expression of human tRNA genes drives the abundance of tRNA-derived fragments.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Dimerization confers increased stability to nucleases in 5' halves from glycine and glutamic acid tRNAs.Nucleic acids research · 2018Article
- Modifications and functional genomics of human transfer RNA.Cell research · 2018Review
- Data Mining of Small RNA-Seq Suggests an Association Between Prostate Cancer and Altered Abundance of 5' Transfer RNA Halves in Seminal Fluid and Prostatic Tissues.Biomarkers in cancer · 2018Article
- Transfer-RNA-mediated enhancement of ribosomal proteins S6 kinases signaling for cell proliferation.RNA biology · 2018Article
- Swellix: a computational tool to explore RNA conformational space.BMC bioinformatics · 2017Article
- Determination of tRNA aminoacylation levels by high-throughput sequencing.Nucleic acids research · 2017Article
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- GtRNAdb 2.0: an expanded database of transfer RNA genes identified in complete and draft genomes.Nucleic acids research · 2016Article
- Emerging roles of tRNA in adaptive translation, signalling dynamics and disease.Nature reviews. Genetics · 2015Review
- Article
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4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Several classes of small noncoding RNAs are key players in cellular metabolism including mRNA decoding, RNA processing, and mRNA stability. Here we show that a tRNA(Asp) isodecoder, corresponding to a human tRNA-derived sequence, binds to an embedded Alu RNA element contained in the 3' UTR of the human aspartyl-tRNA synthetase mRNA. This interaction between two well-known classes of RNA molecules, tRNA and Alu RNA, is driven by an unexpected structural motif and induces a global rearrangement of the 3' UTR. Besides, this 3' UTR contains two functional polyadenylation signals. We propose a model where the tRNA/Alu interaction would modulate the accessibility of the two alternative polyadenylation sites and regulate the stability of the mRNA. This unique regulation mechanism would link gene expression to RNA polymerase III transcription and may have implications in a primate-specific signal pathway.
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