ArticleJournal of neuroscience methods2011
Tonic and phasic release of glutamate and acetylcholine neurotransmission in sub-regions of the rat prefrontal cortex using enzyme-based microelectrode arrays.
Article in Journal of neuroscience methods, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing.Biosensors · 2025Review
- Cortico-striatal action control inherent of opponent cognitive-motivational styles.bioRxiv : the preprint server for biology · 2024Article
- Article
- Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters.Molecular and cellular neurosciences · 2023Article
- A neural probe for concurrent real-time measurement of multiple neurochemicals with electrophysiology in multiple brain regions in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Echem methods and electrode types of the currentRSC advances · 2022Review
- Cell-Type Specific Neuromodulation of Excitatory and Inhibitory NeuronsFrontiers in neural circuits · 2022Article
- Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits Is Cooperative and Cell-Specific.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Diverse Spatiotemporal Scales of Cholinergic Signaling in the Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Review
- Challenges of simultaneous measurements of brain extracellular GABA and glutamate in vivo using enzyme-coated microelectrode arrays.Journal of neuroscience methods · 2020Article
- Neuromodulators and Long-Term Synaptic Plasticity in Learning and Memory: A Steered-Glutamatergic Perspective.Brain sciences · 2019Review
- Developing Next-generation Brain Sensing Technologies - A Review.IEEE sensors journal · 2019Article
- Pt-grown carbon nanofibers for enzymatic glutamate biosensors and assessment of their biocompatibility.RSC advances · 2018Article
- The role of glutamate signaling in incentive salience: second-by-second glutamate recordings in awake Sprague-Dawley rats.Journal of neurochemistry · 2018Article
- Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo.eLife · 2018Article
- Peripherally restricted viral challenge elevates extracellular glutamate and enhances synaptic transmission in the hippocampus.Journal of neurochemistry · 2016Article
- Microfabricated, amperometric, enzyme-based biosensors for in vivo applications.Analytical and bioanalytical chemistry · 2016Review
- Real-time monitoring of extracellular adenosine using enzyme-linked microelectrode arrays.Biosensors & bioelectronics · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The medial prefrontal cortex (mPFC) is an area of the brain critical for higher cognitive processes and implicated in disorders of the CNS such as drug addiction, depression and schizophrenia. Glutamate and acetylcholine are neurotransmitters that are essential for cortical functioning, yet little is known about the dynamic function of these neurotransmitters in subregions of the mPFC. In these studies we used a novel microelectrode array technology to measure resting levels (tonic release) of glutamate and acetylcholine as well as KCl-evoked release (stimulated phasic release) in the mPFC of the anesthetized rat to further our understanding of both tonic and phasic neurotransmission in the cingulate cortex, prelimbic cortex, and infralimbic cortex of the mPFC. Studies revealed homogeneity of tonic and phasic signaling among brain subregions for each neurotransmitter. However, resting levels of glutamate were significantly higher as compared to acetylcholine levels in all subregions. Additionally, KCl-evoked acetylcholine release in the cingulate cortex (7.1 μM) was significantly greater than KCl-evoked glutamate release in any of the three subregions (Cg1, 2.9 μM; PrL, 2.0 μM; IL, 1.8 μM). Interestingly, the time for signal decay following KCl-evoked acetylcholine release was significantly longer by an average of 240% as compared to KCL-evoked glutamate release for all three brain subregions. Finally, we observed a negative relationship between acetylcholine resting levels and KCl-evoked release in the Cg1. These data suggest a homogenous distribution of both glutamatergic and acetylcholinergic innervation in the mPFC, with alterations in tonic and phasic release regulation accounting for differences between these neurotransmitters.
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Registered trials
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