ArticleNeuropharmacology2011
Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats.
Article in Neuropharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Chronic Nicotine Exposure Alters Metabotropic Glutamate Receptor 5: Longitudinal PET Study and Behavioural Assessment in Rats.Neurotoxicity research · 2019Article
- PKMζ in the nucleus accumbens acts to dampen cocaine seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Metabotropic Glutamate Receptor 5 as a Target for the Treatment of Depression and Smoking: Robust Preclinical Data but Inconclusive Clinical Efficacy.Biological psychiatry · 2018Review
- Behavioral changes after nicotine challenge are associated with α7 nicotinic acetylcholine receptor-stimulated glutamate release in the rat dorsal striatum.Scientific reports · 2017Article
- Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats.Psychopharmacology · 2016Article
- Glutamatergic transmission in drug reward: implications for drug addiction.Frontiers in neuroscience · 2015Review
- Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats.Acta pharmacologica Sinica · 2014Article
- Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Involvement of glutamatergic and GABAergic systems in nicotine dependence: Implications for novel pharmacotherapies for smoking cessation.Neuropharmacology · 2014Review
- Intravenous nicotine injection induces rapid, experience-dependent sensitization of glutamate release in the ventral tegmental area and nucleus accumbens.Journal of neurochemistry · 2013Article
- Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The "stop" and "go" of nicotine dependence: role of GABA and glutamate.Cold Spring Harbor perspectives in medicine · 2013Review
- Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions in mice.Psychopharmacology · 2013Article
- The volitional nature of nicotine exposure alters anandamide and oleoylethanolamide levels in the ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice.PloS one · 2013Article
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2 authors.
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Abstract
Systemic administration of the mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) was previously shown to selectively attenuate nicotine self-administration without affecting food-maintained responding in rats. Glutamatergic neurotransmission in the ventral tegmental area (VTA) and nucleus accumbens (NAcc) shell plays an important role in the reinforcing effects of nicotine. To determine the brain sites that may mediate the systemic effects of MPEP on nicotine self-administration, the present study investigated the effects of MPEP microinfusions into the VTA or the NAcc shell on nicotine and food self-administration in separate groups of rats. Administration of low MPEP doses (0, 0.5, 1, and 2 μg/0.5 μl/side) microinfused into the NAcc shell had no effect on nicotine self-administration, whereas higher MPEP doses (0, 10, 20, and 40 μg/0.5 μl/side) microinfused into the NAcc shell dose-dependently attenuated nicotine self-administration without affecting food-maintained responding. Microinfusions of MPEP into the VTA (0, 10, 20, and 40 μg/0.5 μl/side) significantly decreased both nicotine and food self-administration at 20 μg/0.5 μl/side but did not affect responding for either reinforcer at 40μg/0.5 μl/side. This lack of effect of 40 μg/0.5 μl/side MPEP on either nicotine or food self-administration when administered into the VTA may be attributable either to actions of MPEP at presynaptic mGlu5 receptors or at targets other than mGlu5 receptors. Importantly, anatomical control injections 2mm above the NAcc shell or the VTA using the most effective MPEP dose in the two regions did not result in attenuation of nicotine self-administration. In conclusion, MPEP microinfusions in the VTA or NAcc shell attenuates the reinforcing effects of nicotine possibly via blockade of mGlu5 receptors located in these regions.
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