ArticleThe British journal of nutrition2012
Plasma appearance and disappearance of an oral dose of 25-hydroxyvitamin D2 in healthy adults.
Article in The British journal of nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- 25(OH)D2 half-life is shorter than 25(OH)D3 half-life and is influenced by DBP concentration and genotype.The Journal of clinical endocrinology and metabolism · 2014Trial
- Obesity may extend the time required to reach a steady-state 25(OH)D level after initiating vitamin D supplementation.JBMR plus · 2025Article
- Search for Disease-Specific Genetic Markers Originated from the Vitamin D Binding Protein Gene Polymorphisms in the Multiple Sclerosis Cohort in the Latvian Population.International journal of molecular sciences · 2025Article
- Interplay between Vitamin D and Adipose Tissue: Implications for Adipogenesis and Adipose Tissue Function.Nutrients · 2023Review
- Review
- Vitamin D kinetics in nonpregnant and pregnant women after a single oral dose of trideuterated vitamin DThe Journal of steroid biochemistry and molecular biology · 2022Article
- The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology-a narrative overview of the literature.Annals of translational medicine · 2021Review
- Analytical Bias in the Measurement of Plasma 25-Hydroxyvitamin D Concentrations in Infants.International journal of environmental research and public health · 2020Article
- Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective.The Journal of steroid biochemistry and molecular biology · 2019Article
- Review
- Three Sisters With Heterozygous Gene Variants ofJournal of the Endocrine Society · 2019Article
- Vitamin D expenditure is not altered in pregnancy and lactation despite changes in vitamin D metabolite concentrations.Scientific reports · 2016Article
- Review
- Article
- Predictors of 25(OH)D half-life and plasma 25(OH)D concentration in The Gambia and the UK.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Predictors of intact and C-terminal fibroblast growth factor 23 in Gambian children.Endocrine connections · 2014Article
- Vitamin D supplementation in a healthy, middle-aged population: actual practices based on data from a French comprehensive regional health-care database.European journal of clinical nutrition · 2013Article
- Vitamin D3 supplementation scheme in HIV-infected patients based upon pharmacokinetic modelling of 25-hydroxycholecalciferol.British journal of clinical pharmacology · 2013Article
- The problems of vitamin d insufficiency in older people.Aging and disease · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
25-Hydroxyvitamin D (25(OH)D) half-life is a potential biomarker for investigating vitamin D metabolism and requirements. We performed a pilot study to assess the approach and practical feasibility of measuring 25(OH)D half-life after an oral dose. A total of twelve healthy Gambian men aged 18-23 years were divided into two groups to investigate the rate and timing of (1) absorption and (2) plasma disappearance after an 80 nmol oral dose of 25(OH)D2. Fasting blood samples were collected at baseline and, in the first group, every 2 h post-dose for 12 h, at 24 h, 48 h and on day 15. In the second group, fasting blood samples were collected on days 3, 4, 5, 6, 9, 12, 15, 18 and 21. Urine was collected for 2 h after the first morning void at baseline and on day 15. 25(OH)D2 plasma concentration was measured by ultra-performance liquid chromatography-tandem MS/MS and corrected for baseline. Biomarkers of vitamin D, Ca and P metabolism were measured at baseline and on day 15. The peak plasma concentration of 25(OH)D2 was 9·6 (sd 0·9) nmol/l at 4·4 (sd 1·8) h. The terminal slope of 25(OH)D2 disappearance was identified to commence from day 6. The terminal half-life of plasma 25(OH)D2 was 13·4 (sd 2·7) d. There were no significant differences in plasma 25(OH)D3, total 1,25(OH)2D, parathyroid hormone, P, Ca and ionised Ca and urinary Ca and P between baseline and day 15 and between the two groups. The present study provides data on the plasma response to oral 25(OH)D2 that will underpin and contribute to the further development of studies to investigate 25(OH)D half-life.
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