ArticleImmunology2011
Protective immunity against the gastrointestinal nematode Nippostrongylus brasiliensis requires a broad T-cell receptor repertoire.
Article in Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
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- Examination of Horizontal Transmission ofJournal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Induction of Siglec-FFrontiers in immunology · 2023Article
- ILCs-Crucial Players in Enteric Infectious Diseases.International journal of molecular sciences · 2022Review
- Emergent and Neglected Equine Filariosis in Egypt: Species Diversity and Host Immune Response.Pathogens (Basel, Switzerland) · 2022Article
- Th2 single-cell heterogeneity and clonal distribution at distant sites in helminth-infected mice.eLife · 2022Article
- Relationship between Th17 immune response and cancer.World journal of clinical oncology · 2021Review
- Transgenic expression of a T cell epitope in Strongyloides ratti reveals that helminth-specific CD4+ T cells constitute both Th2 and Treg populations.PLoS pathogens · 2021Article
- Single cell analysis of host response to helminth infection reveals the clonal breadth, heterogeneity, and tissue-specific programming of the responding CD4+ T cell repertoire.PLoS pathogens · 2021Article
- Th1/Th2 balance and humoral immune response to potential antigens as early diagnostic method of equineVeterinary world · 2017Article
- Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages.Immunology · 2016Review
- Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection.PLoS pathogens · 2013Article
- Development of CD4 T Cell Dependent Immunity Against N. brasiliensis Infection.Frontiers in immunology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The parasitic gastrointestinal nematode Nippostrongylus brasiliensis induces massive expansion of T helper type 2 (Th2) cells in the lung and small intestine. Th2 cells are a major source of interleukin-4 and interleukin-13, two cytokines that appear essential for rapid worm expulsion. It is unclear whether all Th2 cells induced during infection are pathogen-specific because Th2 cells might also be induced by parasite-derived superantigens or cytokine-mediated bystander activation. Bystander Th2 polarization could explain the largely unspecific B-cell response during primary infection. Furthermore, it is not known whether protective immunity depends on a polyclonal repertoire of T-cell receptor (TCR) specificities. To address these unresolved issues, we performed adoptive transfer experiments and analysed the TCR-Vβ repertoire before and after infection of mice with the helminth N. brasiliensis. The results demonstrate that all Th2 cells were generated by antigen-specific rather than superantigen-driven or cytokine-driven activation. Furthermore, we show that worm expulsion was impaired in mice with a limited repertoire of TCR specificities, indicating that a polyclonal T-cell response is required for protective immunity.
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