ArticleImmunology2011
Differential modulating effect of natural killer (NK) T cells on interferon-γ production and cytotoxic function of NK cells and its relationship with NK subsets in Chlamydia muridarum infection.
Article in Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Role of IFN-γ from Different Immune Cells inMicroorganisms · 2025Review
- Benign breast tumors may arise on different immunological backgrounds.Molecular oncology · 2024Article
- Enhancement of Macrophage Immunity against Chlamydial Infection by Natural Killer T Cells.Cells · 2024Article
- Pathogenic NKT cells attenuate urogenital chlamydial clearance and enhance infertility.Scandinavian journal of immunology · 2023Article
- Article
- [Inhibition of CD96 enhances interferon-γ secretion by natural killer cells to alleviate lung injury in mice with pulmonaryNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- An Ancient Molecular Arms Race:Frontiers in immunology · 2020Review
- The Important Role of Dendritic Cell (DC) in iNKT-Mediated Modulation of NK Cell Function in Chlamydia pneumoniae Lung Infection.Mediators of inflammation · 2019Article
- Natural killer cells regulate Th1/Treg and Th17/Treg balance in chlamydial lung infection.Journal of cellular and molecular medicine · 2016Article
- Accumulation of invariant NKT cells with increased IFN-γ production in persistent high-risk HPV-infected high-grade cervical intraepithelial neoplasia.Diagnostic pathology · 2015Article
- Dynamics of NKT-Cell Responses to Chlamydial Infection.Frontiers in immunology · 2015Review
- Chlamydial lung infection induces transient IL-9 production which is redundant for host defense against primary infection.PloS one · 2015Article
- Genital Chlamydia trachomatis: understanding the roles of innate and adaptive immunity in vaccine research.Clinical microbiology reviews · 2014Review
- Interleukin-22 promotes T helper 1 (Th1)/Th17 immunity in chlamydial lung infection.Molecular medicine (Cambridge, Mass.) · 2014Article
- Invariant natural killer T cells: boon or bane in immunity to intracellular bacterial infections?Journal of innate immunity · 2014Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Natural killer T (NKT) cells are a newly identified T-cell population with potential immunomodulatory functions. Several studies have shown modulating effects of NKT cells activated by α-galactosylceramide, a model antigen, on NK cell function. We here report a differential modulating effect of NKT cells on the interferon-γ (IFN-γ) production and cytolytic function of NK cells in a chlamydial infection model, using NKT-cell-deficient mice and antibody blocking (anti-CD1d monoclonal antibody) approaches. Our results showed that both NKT and NK cells became activated and produced IFN-γ following Chlamydia muridarum infection in vitro and in vivo. The NK cells in NKT-cell-deficient mice and CD1d-blocked mice showed decreased CD69 expression, cellular expansion and IFN-γ production but surprisingly showed increased cytolytic activity (degranulation) of immature and more mature NK cell subsets, suggesting an inhibitory role of NKT cells on NK cell killing activity. The results suggest that NKT cells preferentially promote IFN-γ production but are inhibitory for the cytotoxic function of NK cells in this infection model. Furthermore, the differential modulating effect of NKT cells on the IFN-γ production and cytotoxicity of NK cells was observed in immature and mature NK cell subsets, although it was more dramatic in the relatively mature CD11b(high) CD27(high) NK cell subset. This finding demonstrates the complexity of innate cell interactions in infection and the possible differential impact of NKT cells on the variable functional aspects of other cell(s) even in one infection setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.