Evidence map›Paper›PMID 21896006›Full record

ArticleImmunology2011

Are mouse models of human mycobacterial diseases relevant? Genetics says: 'yes!'.

Alexander S Apt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Alexander S AptCentral Institute for Tuberculosis, Moscow, Russia. asapt@aha.ru
Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences · RU

Funding

Immunity to and pathogeneses of M. tuberculosis and M. avium infections in miceR01AI078864 · NIAID · CENTRAL INSTITUTE FOR TUBERCULOSIS · PI APT, ALEXANDER S · 2008 to 2011
$322k
NIAID NIH HHS R01 AI078864NIAID NIH HHS R01AI078864
6 · The paper itself

Abstract

Relevance and accuracy of experimental mouse models of tuberculosis (TB) are the subject of constant debate. This article briefly reviews genetic aspects of this problem and provides a few examples of mycobacterial diseases with similar or identical genetic control in mice and humans. The two species display more similarities than differences regarding both genetics of susceptibility/severity of mycobacterial diseases and the networks of protective and pathological immune reactions. In the opinion of the author, refined mouse models of mycobacterial diseases are extremely useful for modelling the corresponding human conditions, if genetic diversity is taken into account.

Indexed as

Disease Models, AnimalAnimalsCation Transport ProteinsGene Knockout TechniquesGenetic Predisposition to DiseaseGenetic VariationHumansImmune System DiseasesInterferon Regulatory Factor-8Interferon Regulatory FactorsMiceMinor Histocompatibility AntigensMultifactorial InheritanceNatural Resistance-associated Macrophage Protein 1Nuclear ProteinsSeverity of Illness IndexCation Transport ProteinsIfi75 protein, mouseInterferon Regulatory Factor-8Interferon Regulatory FactorsMinor Histocompatibility AntigensNatural Resistance-associated Macrophage Protein 1Nuclear ProteinsSp110 protein, humanTrans-Activators

Identifiers

PMID21896006
PMCPMC3194219
OpenAlexW1568348877

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.