Trial reportTransfusion2012
Providing ABO-identical platelets and cryoprecipitate to (almost) all patients: approach, logistics, and associated decreases in transfusion reaction and red blood cell alloimmunization incidence.
Trial report in Transfusion, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Transfusion and component characteristics are not associated with allergic transfusion reactions to apheresis platelets.Transfusion · 2015Trial
- Associations between blood donors, component modifications, and the alloimmunization of transfusion recipients.Transfusion · 2025Article
- Molecular advances in transfusion medicine: a narrative review.Frontiers in medicine · 2025Review
- A commentary on the optimal red blood cell transfusion threshold in acute leukemia patients.Blood transfusion = Trasfusione del sangue · 2023Article
- A2B Blood Group Without Anti-A1 Lectin Antibodies in a Child With an Enzymopathy Hemolytic Disease.Cureus · 2021Article
- Does ABO and RhD matching matter for platelet transfusion?Hematology. American Society of Hematology. Education Program · 2020Review
- Comparative Study for Measurement of Residual Leucocytes in Leucodepleted Red Blood Cells by Two Different Methods.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2020Article
- ABO-incompatible platelets are associated with increased transfusion reaction rates.Transfusion · 2020Article
- Neonatal and pediatric platelet transfusions: current concepts and controversies.Current opinion in hematology · 2019Review
- Acute Intravascular Hemolysis Following an ABO Non-Identical Platelet Transfusion: A Case Report and Literature Review.The American journal of case reports · 2019Review
- Effects of ABO Matching of Platelet Transfusions in Critically Ill Children.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2019Observational
- ABO matching of platelet transfusions - "Start Making Sense". "As we get older, and stop making sense…" - The Talking Heads (1984).Blood transfusion = Trasfusione del sangue · 2015Article
- Transfusion of ABO non-identical platelets does not influence the clinical outcome of patients undergoing autologous haematopoietic stem cell transplantation.Blood transfusion = Trasfusione del sangue · 2015Article
- Platelet transfusion - the new immunology of an old therapy.Frontiers in immunology · 2015Review
- Recent Advances in Preventing Adverse Reactions to Transfusion.F1000Research · 2015Review
- Scratching the surface of allergic transfusion reactions.Transfusion · 2013Review
- Platelet transfusion - the art and science of compromise.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2013Article
- CD40 ligand (CD154) involvement in platelet transfusion reactions.Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine · 2012Review
- Use of Cryoprecipitate in Newborn Infants.Newborn (Clarksville, Md.)Article
- Current trends in platelet transfusions practice: The role of ABO-RhD and human leukocyte antigen incompatibility.Asian journal of transfusion scienceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundThere are multiple benefits to transfusing only ABO-identical blood components. Historically our institution routinely transfused ABO-nonidentical platelets (PLTs) and cryoprecipitate to surgical patients. In April 2005, we implemented a policy of transfusing only ABO-identical components whenever feasible, regardless of outdating or logistic considerations. STUDY DESIGN AND
methodsTechnical staff closely monitored product usage and adjusted blood center orders based on recent utilization and planned transfusions. When unable to provide ABO-identical PLTs, ABO-compatible PLTs were washed to remove incompatible plasma. Data on outdating were collected for 18 months before and after implementation. We compared transfusion reaction and red blood cell (RBC) alloimmunization incidence for 4 years preceding (2001-2004) and subsequent (2006-2009) to implementation.
resultsIn the year after implementation, only 11 of 410 surgical patients received ABO-nonidentical PLTs (2.7%). There was a 5.6% increase in outdating of PLTs. Transfusing ABO-identical components was associated with significant reductions in febrile (-46%; 8.0 to 4.3 per 10,000 components; p < 0.0001) and allergic transfusion reactions (-23%; from 7.0 to 5.4 per 10,000 components; p = 0.025). A progressive reduction in de novo RBC alloimmunization incidence also occurred (-50% by 2009; p = 0.03).
conclusionsProviding ABO-identical PLTs to almost all patients was feasible in our setting by changing ordering and inventorying procedures and making the ABO-identical policy a staff priority. Unexpected and striking reductions in febrile and allergic reactions and RBC alloimmunization were observed, of uncertain causal relationship to this ABO policy change, which will require further study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.