ArticleJournal of biomedical optics2011
Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis.
Article in Journal of biomedical optics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Prediction of biomechanical properties of ex vivo human femoral cortical bone using Raman spectroscopy and machine learning algorithms.Bone reports · 2025Article
- Predicting bone aging using spatially offset Raman spectroscopy: a longitudinal analysis on mice.Analytical and bioanalytical chemistry · 2025Article
- Antiresorptive effect of a semisynthetic triterpene from Combretum leprosum Mart. on dexamethasone-induced osteoporosis in rats.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Article
- Detection of osteoporotic-related bone changes and prediction of distal radius strength using Raman spectra from excised human cadaver finger bones.Journal of biomechanics · 2023Article
- Role of the Mitochondrial Permeability Transition in Bone Metabolism and Aging.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- About the mechanism of ultrasonically induced protein capsule formation.RSC advances · 2021Article
- Improved prediction of femoral fracture toughness in mice by combining standard medical imaging with Raman spectroscopy.Journal of biomechanics · 2021Article
- Soft-tissue spectral subtraction improves transcutaneous Raman estimates of murine bone strength in vivo.Journal of biophotonics · 2020Article
- Raman spectroscopy applications in rheumatology.Lasers in medical science · 2019Review
- Spatially offset Raman spectroscopy forBiomedical optics express · 2018Article
- Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue.Journal of biophotonics · 2017Article
- Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy.Sensors (Basel, Switzerland) · 2017Review
- Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue.Biomedical optics express · 2015Article
- Single exosome study reveals subpopulations distributed among cell lines with variability related to membrane content.Journal of extracellular vesicles · 2015Article
- Asfotase-α improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1.Nature medicine · 2014Article
- The loss of activating transcription factor 4 (ATF4) reduces bone toughness and fracture toughness.Bone · 2014Article
- Polarization in Raman spectroscopy helps explain bone brittleness in genetic mouse models.Journal of biomedical optics · 2014Article
- Overconstrained library-based fitting method reveals age- and disease-related differences in transcutaneous Raman spectra of murine bones.Journal of biomedical optics · 2013Article
- Effects of pathology dyes on Raman bone spectra.Journal of biomedical optics · 2013Article
- Polarization control of Raman spectroscopy optimizes the assessment of bone tissue.Journal of biomedical optics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Although glucocorticoids are frequently prescribed for the symptomatic management of inflammatory disorders such as rheumatoid arthritis, extended glucocorticoid exposure is the leading cause of physician-induced osteoporosis and leaves patients at a high risk of fracture. To study the biochemical effects of glucocorticoid exposure and how they might affect biomechanical properties of the bone, Raman spectra were acquired from ex vivo tibiae of glucocorticoid- and placebo-treated wild-type mice and a transgenic mouse model of rheumatoid arthritis. Statistically significant spectral differences were observed due to both treatment regimen and mouse genotype. These differences are attributed to changes in the overall bone mineral composition, as well as the degree of phosphate mineralization in tibial cortical bone. In addition, partial least squares regression was used to generate a Raman-based prediction of each tibia's biomechanical strength as quantified by a torsion test. The Raman-based predictions were as accurate as those produced by microcomputed tomography derived parameters, and more accurate than the clinically-used parameter of bone mineral density. These results suggest that Raman spectroscopy could be a valuable tool for monitoring bone biochemistry in studies of bone diseases such as osteoporosis, including tests of drugs being developed to combat these diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.