ArticleThe Journal of chemical physics2011
Electrostatics and aggregation: how charge can turn a crystal into a gel.
Article in The Journal of chemical physics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Prediction of Antibody Viscosity from Dilute Solution Measurements.Antibodies (Basel, Switzerland) · 2023Article
- Effects of non-pairwise repulsion on nanoparticle assembly.The Journal of chemical physics · 2019Article
- SLTCAP: A Simple Method for Calculating the Number of Ions Needed for MD Simulation.Journal of chemical theory and computation · 2018Article
- Ion Specificity and Nonmonotonic Protein Solubility from Salt Entropy.Biophysical journal · 2018Article
- Stable, metastable, and kinetically trapped amyloid aggregate phases.Biomacromolecules · 2015Article
- Novel kinetic trapping in charged colloidal clusters due to self-induced surface charge organization.Scientific reports · 2013Article
- Growth rates of protein crystals.Journal of the American Chemical Society · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The crystallization of proteins or colloids is often hindered by the appearance of aggregates of low fractal dimension called gels. Here we study the effect of electrostatics upon crystal and gel formation using an analytic model of hard spheres bearing point charges and short range attractive interactions. We find that the chief electrostatic free energy cost of forming assemblies comes from the entropic loss of counterions that render assemblies charge-neutral. Because there exists more accessible volume for these counterions around an open gel than a dense crystal, there exists an electrostatic entropic driving force favoring the gel over the crystal. This driving force increases with increasing sphere charge, but can be counteracted by increasing counterion concentration. We show that these effects cannot be fully captured by pairwise-additive macroion interactions of the kind often used in simulations, and we show where on the phase diagram to go in order to suppress gel formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.