ArticleAnalytical chemistry2011
Ratio analysis nuclear magnetic resonance spectroscopy for selective metabolite identification in complex samples.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Metabolite Fraction Libraries for Quantitative NMR Metabolomics.Analytical chemistry · 2026Article
- Metabolite Fraction Libraries for Quantitative NMR Metabolomics.bioRxiv : the preprint server for biology · 2025Article
- Identification and Distribution of the Dietary Antioxidant Ergothioneine in Humans and Animal Models Combining NMR, RANSY, and MS Methods.Analytical chemistry · 2025Article
- Metabolomics analysis of anaphylactoid reactions induced by Xueshuantong injection in normal and immunocompromised mice.Frontiers in pharmacology · 2024Article
- Multifaceted Analysis of Cerebrospinal Fluid and Serum from Progressive Multiple Sclerosis Patients: Potential Role of Vitamin C and Metal Ion Imbalance in the Divergence of Primary Progressive Multiple Sclerosis and Secondary Progressive Multiple Sclerosis.Journal of proteome research · 2023Article
- Unsupervised Analysis of Small Molecule Mixtures by Wavelet-Based Super-Resolved NMR.Molecules (Basel, Switzerland) · 2023Article
- Analysis of Small-Molecule Mixtures by Super-ResolvedThe journal of physical chemistry. A · 2022Article
- Deep Learning-Based Method for Compound Identification in NMR Spectra of Mixtures.Molecules (Basel, Switzerland) · 2022Article
- Quantitative NMR-Based Biomedical Metabolomics: Current Status and Applications.Molecules (Basel, Switzerland) · 2020Review
- Extractive Ratio Analysis NMR Spectroscopy for Metabolite Identification in Complex Biological Mixtures.Analytical chemistry · 2019Article
- rDolphin: a GUI R package for proficient automatic profiling of 1DMetabolomics : Official journal of the Metabolomic Society · 2018Article
- Accurate Identification of Unknown and Known Metabolic Mixture Components by Combining 3D NMR with Fourier Transform Ion Cyclotron Resonance Tandem Mass Spectrometry.Journal of proteome research · 2017Article
- The future of NMR-based metabolomics.Current opinion in biotechnology · 2017Review
- Can NMR solve some significant challenges in metabolomics?Journal of magnetic resonance (San Diego, Calif. : 1997) · 2015Review
- Quantitating metabolites in protein precipitated serum using NMR spectroscopy.Analytical chemistry · 2014Article
- RAMSY: ratio analysis of mass spectrometry to improve compound identification.Analytical chemistry · 2013Article
- Introduction of a new critical p value correction method for statistical significance analysis of metabonomics data.Analytical and bioanalytical chemistry · 2013Article
- Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma.Genome medicine · 2013Article
- NMR Metabolomics Analysis of Parkinson's Disease.Current MetabolomicsArticle
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7 authors.
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Abstract
Metabolite identification in the complex NMR spectra of biological samples is a challenging task due to significant spectral overlap and limited signal-to-noise. In this study we present a new approach, RANSY (ratio analysis NMR spectroscopy), which identifies all the peaks of a specific metabolite on the basis of the ratios of peak heights or integrals. We show that the spectrum for an individual metabolite can be generated by exploiting the fact that the peak ratios for any metabolite in the NMR spectrum are fixed and proportional to the relative numbers of magnetically distinct protons. When the peak ratios are divided by their coefficients of variation derived from a set of NMR spectra, the generation of an individual metabolite spectrum is enabled. We first tested the performance of this approach using one-dimensional (1D) and two-dimensional (2D) NMR data of mixtures of synthetic analogues of common body fluid metabolites. Subsequently, the method was applied to (1)H NMR spectra of blood serum samples to demonstrate the selective identification of a number of metabolites. The RANSY approach, which does not need any additional NMR experiments for spectral simplification, is easy to perform and has the potential to aid in the identification of unknown metabolites using 1D or 2D NMR spectra in virtually any complex biological mixture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.