ArticlePsychopharmacology2012
Nucleus accumbens and delay discounting in rats: evidence from a new quantitative protocol for analysing inter-temporal choice.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- In praise of the hyperbola.Journal of the experimental analysis of behavior · 2026Review
- Impulsivity in NrCAM KO Mice Is Reduced by NMDAR Antagonist MK-801 but Not by AMPAR Antagonist CNQX.NeuroSci · 2026Article
- Delay discounting and nucleus accumbens functional connectivity are related to weight status in adolescents from the ABCD study.Pediatric obesity · 2025Article
- Tyrosine Hydroxylase-Positive Nucleus Accumbens Neurons Influence Delay Discounting in a Mouse T-Maze Task.eNeuro · 2024Article
- Poke And Delayed Drink Intertemporal Choice Task (POKE-ADDICT): An open-source behavioral apparatus for intertemporal choice testing in rodents.Animal models and experimental medicine · 2023Article
- Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Global Cerebral Ischemia in Male Long Evans Rats Impairs Dopaminergic/ΔFosB Signalling in the Mesocorticolimbic Pathway Without Altering Delay Discounting Rates.Frontiers in behavioral neuroscience · 2021Article
- Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds.Psychopharmacology · 2018Review
- Nucleus accumbens core lesions induce sub-optimal choice and reduce sensitivity to magnitude and delay in impulsive choice tasks.Behavioural brain research · 2018Article
- Effects of intra-accumbal administration of dopamine and ionotropic glutamate receptor drugs on delay discounting performance in rats.Behavioral neuroscience · 2017Article
- Increased temporal discounting after chronic stress in CHL1-deficient mice is reversed by 5-HT2C agonist Ro 60-0175.Neuroscience · 2017Article
- Effects of Ventral Striatum Lesions on Stimulus-Based versus Action-Based Reinforcement Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A framework for understanding and advancing intertemporal choice research using rodent models.Neurobiology of learning and memory · 2017Review
- Ramping single unit activity in the medial prefrontal cortex and ventral striatum reflects the onset of waiting but not imminent impulsive actions.The European journal of neuroscience · 2015Article
- Recent Insights into the Neurobiology of Impulsivity.Current addiction reports · 2014Article
- Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task.Behavioral neuroscience · 2014Article
- Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity.The European journal of neuroscience · 2013Article
- Fos expression in the prefrontal cortex and ventral striatum after exposure to a free-operant timing schedule.Behavioural brain research · 2012Article
- A theory of behaviour on progressive ratio schedules, with applications in behavioural pharmacology.Psychopharmacology · 2012Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
rationaleThere is evidence that the core of the nucleus accumbens (AcbC) is involved in inter-temporal choice behaviour.
objectiveA new behavioural protocol was used to examine the effect of destruction of the AcbC on delay discounting in inter-temporal choice schedules in rats.
methodRats with excitotoxic lesions of the AcbC or sham lesions made repeated choices on an adjusting-delay schedule between a smaller reinforcer (A) that was delivered immediately and a larger reinforcer (B) that was delivered after a delay which increased or decreased depending on the subject's choices. In two phases of the experiment, reinforcer sizes were selected which enabled theoretical parameters expressing delay discounting and sensitivity to reinforcer size to be estimated from the ratio of the indifference delays (i.e. the quasi-stable values of the adjusting delay seen after extended training) obtained in the two phases.
resultsIn both groups, indifference delays were shorter when the sizes of A and B were 14 and 25 μl than when they were 25 and 100 μl of a 0.6 M sucrose solution. Indifference delays were shorter in AcbC-lesioned than in sham-lesioned rats. Estimates of delay discounting rate based on the ratio of the indifference delays were lower in the AcbC-lesioned than in the sham-lesioned rats. The size sensitivity parameter did not differ between the groups. Adjusting delays in successive blocks of trials were analysed using Fourier transform. The period corresponding to the dominant frequency of the power spectrum and power within the dominant frequency band did not differ between the groups.
conclusionsDestruction of the AcbC increased the rate of delay discounting.
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21894486What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.