Evidence map›Paper›PMID 21894215›Full record

ArticleNature reviews. Endocrinology2011

A patient with a large recurrent pheochromocytoma demonstrating the pitfalls of diagnosis.

Jörg Singer, Christian A Koch, Woubet Kassahun, Peter Lamesch, Graeme Eisenhofer, Regine Kluge, Thomas Lincke, Matthias Seiwerts, Gudrun Borte, Katrin Schierle and 1 more

Abstract readCase Reports
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In one paragraph

Article in Nature reviews. Endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Ultrasound imaging in the diagnosis of benign and suspicious adrenal lesions.Medical science monitor : international medical journal of experimental and clinical research · 2014
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Jörg SingerDepartment of Endocrinology and Nephrology, University of Leipzig, 04103 Leipzig, Germany.
Christian A Koch
Woubet Kassahun
Peter Lamesch
Graeme Eisenhofer
Regine Kluge
Thomas Lincke
Matthias Seiwerts
Gudrun Borte
Katrin Schierle
Ralf Paschke
Leipzig University · DEKlinikum St. Georg · DEState Street (United States) · USTU Dresden · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA 59-year-old man presented for a follow-up, 6 years after surgery for a large pheochromocytoma. He had suffered from diabetes mellitus, hypertension and abdominal pain in the right flank region. Previous postoperative follow-up did not reveal tumor recurrence. INVESTIGATION: Measurement of plasma free metanephrine and normetanephrine by high-performance liquid chromatography and radioimmunoassay; 123I-metaiodobenzylguanidine (MIBG) scintigraphy; hybrid 123I-MIBG single-photon emission CT (SPECT)-CT; MRI; testing for plasma norepinephrine and epinephrine; intraoperative ultrasonography; histological staining for chromogranin A and synaptophysin; and postoperative 18F-dihydroxyphenylalanine (DOPA) PET scan. DIAGNOSIS: Recurrent pheochromocytoma. MANAGEMENT: Laparotomy with tumor resection. Reduction of antihypertensive medications. Further follow-up by MRI, hybrid 123I-MIBG SPECT-CT and testing for plasma catecholamines and free metanephrines.

Indexed as

Abdominal PainAdrenal Gland NeoplasmsAntihypertensive AgentsChromogranin ADiabetes Mellitus, Type 2EpinephrineHumansHypertensionIodine RadioisotopesMagnetic Resonance ImagingMaleMetanephrineMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalNorepinephrineAntihypertensive AgentsChromogranin AEpinephrineIodine RadioisotopesMetanephrineNorepinephrineNormetanephrineSynaptophysin

Identifiers

PMID21894215
OpenAlexW2011225235

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.