Evidence map›Paper›PMID 21894161›Full record

ArticleInternational journal of obesity (2005)2012

Relation of regional gray and white matter volumes to current BMI and future increases in BMI: a prospective MRI study.

S Yokum, J Ng, E Stice

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of obesity (2005), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 5 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 5 syntheses or guidelines pooled it, 198 citations in OpenAlex.

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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

S YokumOregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA. sonjay@ori.org
J Ng
E Stice
Eugene Research Institute · USOregon Research Institute · USUniversity of Oregon · US

Funding

Risk and Maintenance Factors for Bulimic Pathology (RMI)R01MH064560 · NIMH · UNIVERSITY OF TEXAS AUSTIN · PI STICE, ERIC M · 2002 to 2006
$2.0M
NIMH NIH HHS R01 MH064560NIMH NIH HHS R01 MH 64560A
6 · The paper itself

Abstract

objectiveThis study tested whether global and regional brain volumes correlated with body mass index (BMI) and increases in BMI over 1-year follow-up.

methodsA total of 83 young females (M age=18.4, s.d.=2.8; BMI range=17.3-38.9) were scanned using magnetic resonance imaging. Voxel-based morphometry was used to assess global brain volume and regional gray matter (GM) and white matter (WM) volumes in regions implicated in taste, reward and inhibitory control.

resultsObese participants had less total GM volume than lean and overweight participants. Obese participants had lower total WM volume than overweight participants. BMI correlated with higher WM volumes in the middle temporal gyrus, fusiform gyrus, parahippocampal gyrus, Rolandic operculum and dorsal striatum. Trend-level reduced GM volumes in the superior frontal gyrus and middle frontal gyrus were related to increases in BMI over 1-year follow-up.

conclusionFindings suggest that BMI is related to global and regional differences in brain matter volume in female adolescents. Most importantly, findings suggest that low GM volume in regions implicated in inhibitory control are related to future weight gain. Results taken in conjunction with prior findings suggest that abnormalities in regional GM volumes, but not WM volumes, increase the risk for future weight gain and abnormalities in regional WM volumes, but not GM volumes, are secondary to weight gain.

Indexed as

Body Mass IndexMagnetic Resonance ImagingAdolescentAdultBrainBrain MappingCerebral CortexFemaleHumansLimbic SystemObesityProspective StudiesRewardYoung Adult

Identifiers

PMID21894161
PMCPMC3982917
OpenAlexW2042132077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.