ArticleArchives of pediatrics & adolescent medicine2012
Prevalence of polypharmacy exposure among hospitalized children in the United States.
Article in Archives of pediatrics & adolescent medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Contraindicated drug-drug interactions in hospitalized children: A low prevalence that warrants methodological scrutiny.British journal of clinical pharmacology · 2026Article
- Contraindicated drug-drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients.British journal of clinical pharmacology · 2026Observational
- Polypharmacy and Drug Interaction Risk in Children and Adolescents with Congenital Heart Defects: Insights from a Nationwide Survey.Journal of clinical medicine · 2026Article
- Association between polypharmacy and clinical outcomes in children with medical complexity: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- Potential drug-drug interactions and associated factors among hospitalized pediatric patients in Adigrat general hospital, Tigrai, north Ethiopia: a retrospective cross-sectional study.BMC pediatrics · 2024Article
- A coordinated approach for managing polypharmacy among children with medical complexity: rationale and design of the Pediatric Medication Therapy Management (pMTM) randomized controlled trial.BMC health services research · 2023Article
- Population pharmacokinetics in critically ill neonates and infants undergoing extracorporeal membrane oxygenation: a literature review.BMJ paediatrics open · 2022Review
- Article
- A whole blood microsampling furosemide assay: development, validation and use in a pediatric pharmacokinetic study.Bioanalysis · 2022Article
- Development, validation, and implementation of an UHPLC-MS/MS method for the quantitation of furosemide in infant urine samples.Biomedical chromatography : BMC · 2022Article
- Patterns of Medication Prescription among Children and Adolescents with Attention-Deficit/Hyperactivity Disorder in the United States.Children (Basel, Switzerland) · 2022Article
- Chronic Medication Use and Factors Associated With Polypharmacy Among Outpatient Pediatric Patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Medications Reconciled at Discharge Versus Admission Among Inpatients at a Children's Hospital.Hospital pediatrics · 2021Article
- Opioid-Induced Respiratory Depression in Pediatric Palliative Care Patients with Severe Neurological Impairment-A Scoping Literature Review and Case Reports.Children (Basel, Switzerland) · 2020Article
- Prevalence of Clinically Significant Drug-Drug Interactions Across US Children's Hospitals.Pediatrics · 2020Article
- A Scoping Review of Medications Studied in Pediatric Polypharmacy Research.Paediatric drugs · 2020Article
- Biomaterial-Driven Immunomodulation: Cell Biology-Based Strategies to Mitigate Severe Inflammation and Sepsis.Frontiers in immunology · 2020Review
- Descriptive study of adverse drug reactions in a tertiary care pediatric hospital in México from 2014 to 2017.PloS one · 2020Article
- Medication use in infants with severe bronchopulmonary dysplasia admitted to United States children's hospitals.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Choosing medications wisely: Is it time to address paediatric polypharmacy?Paediatrics & child health · 2019Article
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo assess the prevalence and patterns of exposure to drugs and therapeutic agents among hospitalized pediatric patients.
designRetrospective cohort study.
settingA total of 411 general hospitals and 52 children's hospitals throughout the United States. PATIENTS: A total of 587 427 patients younger than 18 years, excluding healthy newborns, hospitalized in 2006, representing one-fifth of all pediatric admissions in the United States.
main outcome measuresDaily and cumulative exposure to drugs and therapeutic agents.
resultsThe most common exposures varied by patient age and by hospital type, with acetaminophen, albuterol, various antibiotics, fentanyl, heparin, ibuprofen, morphine, ondansetron, propofol, and ranitidine being among the most prevalent exposures. A considerable fraction of patients were exposed to numerous medications: in children's hospitals, on the first day of hospitalization, patients younger than 1 year at the 90th percentile of daily exposure to distinct medications received 11 drugs, and patients 1 year or older received 13 drugs; in general hospitals, 8 and 12 drugs, respectively. By hospital day 7, in children's hospitals, patients younger than 1 year at the 90th percentile of cumulative exposure to distinct distinct medications had received 29 drugs, and patients 1 year or older had received 35; in general hospitals, 22 and 28 drugs, respectively. Patients with less common conditions were more likely to be exposed to more drugs (P = .001).
conclusionA large fraction of hospitalized pediatric patients are exposed to substantial polypharmacy, especially patients with rare conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.