ReviewThe Journal of physiology2012
Ca(2+) permeable AMPA receptors switch allegiances: mechanisms and consequences.
Review in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Shank3 establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and is associated with altered regional microglial morphology.Neurobiology of disease · 2025Article
- Age-Related Transcriptomic Changes in the Vermiform Appendix.International journal of molecular sciences · 2025Article
- Ethanol self-administration targets GluA2-containing AMPA receptor expression and synaptic activity in the nucleus accumbens in a manner that drives the positive reinforcing properties of the drug.Psychopharmacology · 2025Article
- Review
- Novel GRIA2 variant in a patient with atypical autism spectrum disorder and psychiatric symptoms: a case report.BMC pediatrics · 2022Article
- Acute neurotoxicant exposure induces hyperexcitability in mouse lumbar spinal motor neurons.Journal of neurophysiology · 2020Article
- PKA-Dependent Membrane Surface Recruitment of CI-AMPARs Is Crucial for BCP-Mediated Protection Against Post-acute Ischemic Stroke Cognitive Impairment.Frontiers in neurology · 2020Article
- Ocular Hypertension Drives Remodeling of AMPA Receptors in Select Populations of Retinal Ganglion Cells.Frontiers in synaptic neuroscience · 2020Article
- AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.Nature communications · 2019Article
- Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons.Neuron · 2017Article
- Role of AMPA receptors in homocysteine-NMDA receptor-induced crosstalk between ERK and p38 MAPK.Journal of neurochemistry · 2017Article
- Neuroprotective effects of autophagy inhibition on hippocampal glutamate receptor subunits after hypoxia-ischemia-induced brain damage in newborn rats.Neural regeneration research · 2017Article
- Exercise-Induced Neuroprotection of the Nigrostriatal Dopamine System in Parkinson's Disease.Frontiers in aging neuroscience · 2017Review
- Gangliosides of the Vertebrate Nervous System.Journal of molecular biology · 2016Review
- miR-501-3p mediates the activity-dependent regulation of the expression of AMPA receptor subunit GluA1.The Journal of cell biology · 2015Article
- A Model of In vitro Plasticity at the Parallel Fiber-Molecular Layer Interneuron Synapses.Frontiers in computational neuroscience · 2015Article
- Impaired ILK Function Is Associated with Deficits in Hippocampal Based Memory and Synaptic Plasticity in a FASD Rat Model.PloS one · 2015Article
- Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities.Molecular psychiatry · 2014Article
- Ganglioside regulation of AMPA receptor trafficking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Depletion of 14-3-3γ reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death.Molecular brain · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The subunit composition of synaptic AMPA receptors can undergo dynamic changes during physiological functioning and under pathological conditions. This switch in AMPA receptor phenotype involves changes in the level of GluA2 subunits that are mediated via regulated AMPA receptor trafficking, modification of local protein synthesis and altered gene transcription of GluA2 subunits. Incorporation of the GluA2 subunits into an AMPA receptor alters a number of key biophysical properties, including Ca(2+) permeability and the waveform of the synaptic current. These changes alter the ability of synaptic currents to evoke an action potential and therefore have a profound effect on the computational capability of individual neurons and thus the output of neuronal circuits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.