ArticleBiomaterials2011
Real time monitoring of biomaterial-mediated inflammatory responses via macrophage-targeting NIR nanoprobes.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
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- Current Development of Nano-Drug Delivery to Target Macrophages.Biomedicines · 2022Review
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- A pretargeting nanoplatform for imaging and enhancing anti-inflammatory drug delivery.Bioactive materials · 2020Article
- Near-infrared fluorescence imaging in immunotherapy.Advanced drug delivery reviews · 2020Review
- Bioresponsive drug delivery systems for the treatment of inflammatory diseases.Journal of controlled release : official journal of the Controlled Release Society · 2020Review
- Imaging in Chronic Wound Diagnostics.Advances in wound care · 2020Review
- Chemokine releasing particle implants for trapping circulating prostate cancer cells.Scientific reports · 2020Article
- Development of a dual-wavelength fluorescent nanoprobe for in vivo and in vitro cell tracking consecutively.Bioorganic & medicinal chemistry · 2019Article
- Screening for new macrophage therapeutics.Theranostics · 2019Review
- Preparation of a novel injectableRSC advances · 2018Article
- Discovering Macrophage Functions UsingFrontiers in immunology · 2018Review
- Hyaluronic Acid-Based Optical Probe for the Diagnosis of Human Osteoarthritic Cartilage.Nanotheranostics · 2018Article
- An optical probe for detecting chondrocyte apoptosis in response to mechanical injury.Scientific reports · 2017Article
- Article
- Design of a portable imager for near-infrared visualization of cutaneous wounds.Journal of biomedical optics · 2017Article
- Ratiometric Reactive Oxygen Species Nanoprobe for Noninvasive In Vivo Imaging of Subcutaneous Inflammation/Infection.Journal of biomedical nanotechnology · 2016Article
- Fluorescence imaging enabled poly(lactide-co-glycolide).Acta biomaterialia · 2016Article
- Nanoparticle ligand presentation for targeting solid tumors.AAPS PharmSciTech · 2014Review
- Development of optical probes for in vivo imaging of polarized macrophages during foreign body reactions.Acta biomaterialia · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Medical implant-mediated inflammatory responses, often involving high levels of macrophages, are typically determined by histological analyses. These methods however are time consuming and require many animals to monitor the kinetics of inflammatory reactions and to generate reproducible outcomes. Recent studies have shown that activated macrophages in inflamed tissue express high levels of folate receptor (FR). In this study, FR-targeting NIR nanoprobes were fabricated and then tested for their ability to detect and quantify the extent of biomaterial-mediated inflammatory responses in vivo. Indeed, FR-targeting nanoprobes preferentially accumulate on activated macrophage surfaces. When administered intravenously, we found that the FR-targeting nanoprobes distinctively gathered in the inflamed tissues and that a different extent of FR-targeting nanoprobe gathering could be found in tissues implanted with different types of biomaterials. Most importantly, we found that there was a good relationship between the extent of inflammatory reactions and the intensity of nanoprobe-associated NIR signal in tissue. Our results support that FR-targeting NIR nanoprobes can be used to monitor and quantify the extent of macrophage recruitment and the degree of an implants' biocompatibility in real time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.