Evidence map›Paper›PMID 21892676›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2012

Effect of supervised and home exercise training on bone mineral density among breast cancer patients. A 12-month randomised controlled trial.

T Saarto, H Sievänen, P Kellokumpu-Lehtinen, R Nikander, L Vehmanen, R Huovinen, H Kautiainen, S Järvenpää, H M Penttinen, M Utriainen and 9 more

2 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 11 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03784651 recruitingnot on this mapstarted 2018, after this paper: background citation

Metabolic and Bone Changes After Adjuvant Cancer Treatments in Early Non-metastatic Breast Cancer - a 5-year Follow-up Study.

TypeobservationalSponsorRigshospitalet, DenmarkRan2018 to 2026Enrolled120ConditionsBone Fracture, Glucose, High Blood, Insulin Resistance, Blood Pressure, High
NCT06190600 naactive not recruitingnot on this mapstarted 2018, after this paper: background citation

Supervised Physical Activity in Young Women With Early Breast Cancer During Neoadjuvant Chemotherpy

TypeinterventionalSponsorThe Greater Poland Cancer CentreRan2018 to 2026Enrolled40ConditionsBreast CancerArmsHigh Intensity Interval Training (HIIT), neoadjuvant treatment (doxorubicin, cyclophosphamide, paclitaxel, trastuzumab, pertuzumab), Standard Supportive Care
3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 11 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
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  4. The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
  5. Exercise for cancer cachexia in adults.The Cochrane database of systematic reviews · 2021
    Pooled it
  6. Pooled it
  7. The effect of exercise on bone mineral density in adult cancer survivors: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Pooled it
  8. Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018
    Pooled it
  9. Pooled it
  10. The effect of physical exercise on bone density in middle-aged and older men: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013
    Pooled it
  11. Pooled it
  12. Trial
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  18. Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 2 countries.

T SaartoDepartment of Oncology, Helsinki University Central Hospital, PO Box 180, Helsinki 00029 HUS, Finland. tiina.saarto@hus.fi
H Sievänen
P Kellokumpu-Lehtinen
R Nikander
L Vehmanen
R Huovinen
H Kautiainen
S Järvenpää
H M Penttinen
M Utriainen
A S Jääskeläinen
A Elme
J Ruohola
T Palva
H Vertio
M Rautalahti
M Fogelholm
R Luoto
C Blomqvist
Helsinki University Hospital · FICancer Society of Finland · FIUrho Kaleva Kekkonen Institute · FITurku University Hospital · FIFinnish Institute for Health and Welfare · FIHospital District of Helsinki and Uusimaa · FIInvalidisäätiö · FITampere University · FIWestCare Foundation · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThe ability of combined step aerobic- and circuit-training to prevent bone loss after breast cancer treatments was related to skeletal site and patients' menopausal status. Among premenopausal breast cancer survivors, a 12-month exercise intervention completely prevented bone loss at the femoral neck, whereas no exercise effect was seen at lumbar spine or at neither site in postmenopausal women.

introductionThe primary objective of this randomised clinical trial was to determine the preventive effect of supervised weight-bearing jumping exercises and circuit training on bone loss among breast cancer patients.

methodsOf 573 breast cancer survivors aged 35-68 years randomly allocated into exercise or control group after adjuvant treatments, 498 (87%) were included in the final analysis. The 12-month exercise intervention comprised weekly supervised step aerobic- and circuit-exercises and similar home training. Bone mineral density (BMD) at lumbar spine and femoral neck were measured by dual-energy X-ray absorptiometry. Physical performance was assessed by 2-km walking and figure-8 running tests, and the amount of physical activity was estimated in metabolic equivalent-hours/week.

resultsIn premenopausal women, bone loss at the femoral neck was prevented by exercise, the mean BMD changes being -0.2% among the trainees vs. -1.4% among the controls (p = 0.01). Lumbar bone loss could not be prevented (-1.9% vs. -2.2%). In postmenopausal women, no significant exercise-effect on BMD was found either at the lumbar spine (-1.6% vs. -2.1%) or femoral neck (-1.1% vs. -1.1%).

conclusionsThis 12-month aerobic jumping and circuit training intervention completely prevented femoral neck bone loss in premenopausal breast cancer patients, whereas no effect on BMD was seen in postmenopausal women.

Indexed as

AdultAgedBody CompositionBody WeightBone DensityBreast NeoplasmsChemotherapy, AdjuvantExercise TherapyFemaleFemur NeckHumansLumbar VertebraeMiddle AgedMotor ActivityOsteoporosisPatient Compliance

Identifiers

PMID21892676
OpenAlexW1964049824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.