ArticlePsychopharmacology2012
Diet-induced obesity blunts the behavioural effects of ghrelin: studies in a mouse-progressive ratio task.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 59 citations in OpenAlex.
- How Do Individually Ventilated Cages Affect the Welfare of Male BALB/c Mice? Comprehensive Assessment of Behavior, Metabolism, and Responses to Acute Painful Stimuli.Brain and behavior · 2025Article
- Article
- The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders.Depression and anxiety · 2024Review
- Effects of junk-food on food-motivated behavior and nucleus accumbens glutamate plasticity; insights into the mechanism of calcium-permeable AMPA receptor recruitment.Neuropharmacology · 2024Article
- Review
- The next big LEAP2 understanding ghrelin function.The Journal of clinical investigation · 2019Article
- Stressing the importance of choice: Validity of a preclinical free-choice high-caloric diet paradigm to model behavioural, physiological and molecular adaptations during human diet-induced obesity and metabolic dysfunction.Journal of neuroendocrinology · 2019Review
- Effect of Maternal Obesity and Preconceptional Weight Loss on Male and Female Offspring Metabolism and Olfactory Performance in Mice.Nutrients · 2019Article
- Regulation of Memory Function by Feeding-Relevant Biological Systems: Following the Breadcrumbs to the Hippocampus.Frontiers in molecular neuroscience · 2019Review
- The cellular and molecular bases of leptin and ghrelin resistance in obesity.Nature reviews. Endocrinology · 2017Review
- Clarifying the Ghrelin System's Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand.International journal of molecular sciences · 2017Review
- Obesity Impairs the Action of the Neuroendocrine Ghrelin System.Trends in endocrinology and metabolism: TEM · 2016Review
- Effects of high-fat diet and gastric bypass on neurons in the caudal solitary nucleus.Physiology & behavior · 2015Article
- Ghrelin signaling is not essential for sugar or fat conditioned flavor preferences in mice.Physiology & behavior · 2015Article
- Gastric bypass in rats does not decrease appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of sugar and fat.Physiology & behavior · 2015Article
- Article
- Ghrelin-Derived Peptides: A Link between Appetite/Reward, GH Axis, and Psychiatric Disorders?Frontiers in endocrinology · 2014Review
- Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward.Frontiers in neuroscience · 2013Review
- Ghrelin signaling in the ventral hippocampus stimulates learned and motivational aspects of feeding via PI3K-Akt signaling.Biological psychiatry · 2013Article
- Effects of diet-induced obesity on motivation and pain behavior in an operant assay.Neuroscience · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationalThe ghrelinergic system is implicated in the development of obesity and in modulating central reward systems. It has been reported that diet-induced obesity causes blunted responding on food intake to ghrelin administration, associated with central ghrelin resistance. Here we investigate whether the stimulatory effects of ghrelin on the reward system are altered in diet-induced obese mice.
methodsObesity was induced in C57BL/6J mice by feeding high-fat diet for 13 weeks. Mice were trained in an operant fixed and exponential progressive ratio task to respond for sucrose rewards. In an ad libitum fed state, ghrelin and a ghrelin receptor antagonist were administered in the progressive ratio. Alterations in the central ghrelin system in diet-induced obese mice were assessed.
resultsObese mice showed attenuated acquisition and performance in the fixed and progressive ratio paradigm. Most importantly, diet-induced obesity inhibited the stimulatory effects of ghrelin (2 nmol, 3 nmol/10 g) on progressive ratio responding whereas lean animals presented with increased responding. Administration of the ghrelin-receptor antagonist (D-Lys(3))-GHRP-6 (66.6 nmol/10 g) decreased performance in lean but not obese mice. This insensitivity to ghrelin receptor ligands in mice on high-fat diet was further supported by decreased mRNA expression of the ghrelin receptor in the hypothalamus and the nucleus accumbens in obese mice.
conclusionsThis study demonstrates that the modulatory effects of ghrelin receptor ligands are blunted in a mouse model of diet-induced obesity in a progressive ratio task. Thereby, our data extend the previously described ghrelin resistance in these mice from food intake to reward-associated behaviours.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.