ArticleMarine drugs2011
Evaluation of Marine Brown Algae and Sponges from Brazil as Anticoagulant and Antiplatelet Products.
Article in Marine drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Chemical Profiling and In Vitro Bioactivities of Extracts from the Red AlgaMarine drugs · 2026Article
- Microalgae: A Promising Source of Valuable Bioproducts.Biomolecules · 2020Review
- Antithrombotics from the Sea: Polysaccharides and Beyond.Marine drugs · 2019Review
- Marine Diterpenes: Molecular Modeling of Thrombin Inhibitors with Potential Biotechnological Application as an Antithrombotic.Marine drugs · 2017Article
- The red seaweed Plocamium brasiliense shows anti-snake venom toxic effects.The journal of venomous animals and toxins including tropical diseases · 2015Article
- Antiplatelet and anticoagulant effects of diterpenes isolated from the marine alga, Dictyota menstrualis.Marine drugs · 2014Article
- Antioxidative effects of extracts from Trifolium species on blood platelets exposed to oxidative stress.Journal of physiology and biochemistry · 2013Article
- Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae).Marine drugs · 2013Article
- Appraisal of antiophidic potential of marine sponges against Bothrops jararaca and Lachesis muta venom.Toxins · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ischemic disorders, in which platelet aggregation and blood coagulation are involved, represent a major cause of disability and death worldwide. The antithrombotic therapy has unsatisfactory performance and may produce side effects. So, there is a need to seek molecules with antithrombotic properties. Marine organisms produce substances with different well defined ecological functions. Moreover, some of these molecules also exhibit pharmacological properties such as antiviral, anticancer, antiophidic and anticoagulant properties. The aim of this study was to evaluate, through in vitro tests, the effect of two extracts of brown algae and ten marine sponges from Brazil on platelet aggregation and blood coagulation. Our results revealed that most of the extracts were capable of inhibiting platelet aggregation and clotting measured by plasma recalcification tests, prothrombin time, activated partial thromboplastin time, and fibrinogenolytic activity. On the other hand, five of ten species of sponges induced platelet aggregation. Thus, the marine organisms studied here may have molecules with antithrombotic properties, presenting biotechnological potential to antithrombotic therapy. Further chemical investigation should be conducted on the active species to discover useful molecules for the development of new drugs to treat clotting disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.