ArticleNature2011
Transcriptomic analysis of avian digits reveals conserved and derived digit identities in birds.
Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- Evolution of limb and digit identity genes since the tetrapod ancestor.Nature communications · 2026Article
- Degeneration and adaptive evolution of digits in ratite birds.Molecular biology and evolution · 2026Article
- Proximal phalanges of digit 1 have different identities in the forelimbs and hindlimbs of the mouse.Scientific reports · 2025Article
- Reduced Expression of CLEC4G in Neurons Is Associated with Alzheimer's Disease.International journal of molecular sciences · 2024Article
- Evidence against tetrapod-wide digit identities and for a limited frame shift in bird wings.Nature communications · 2019Article
- Evolution of the avian digital pattern.Scientific reports · 2019Article
- A single-cell transcriptomic atlas of the developing chicken limb.BMC genomics · 2019Article
- Pervasive Correlated Evolution in Gene Expression Shapes Cell and Tissue Type Transcriptomes.Genome biology and evolution · 2018Article
- Article
- Evolution of antero-posterior patterning of the limb: Insights from the chick.Genesis (New York, N.Y. : 2000) · 2018Review
- Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology.Genome biology · 2017Article
- The origins, scaling and loss of tetrapod digits.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Deep homology in the age of next-generation sequencing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- The origin and evolution of cell types.Nature reviews. Genetics · 2016Review
- Major methylation alterations on the CpG markers of inflammatory immune associated genes after IVIG treatment in Kawasaki disease.BMC medical genomics · 2016Article
- Ancient transposable elements transformed the uterine regulatory landscape and transcriptome during the evolution of mammalian pregnancy.Cell reports · 2015Article
- The phantoms of a high-seven - or - why do our thumbs stick out?Frontiers in zoology · 2015Article
- A relative shift in cloacal location repositions external genitalia in amniote evolution.Nature · 2014Article
- Predictable transcriptome evolution in the convergent and complex bioluminescent organs of squid.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Complete forelimb myology of the basal theropod dinosaur Tawa hallae based on a novel robust muscle reconstruction method.Journal of anatomy · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphological characters are the result of developmental gene expression. The identity of a character is ultimately grounded in the gene regulatory network directing development and thus whole-genome gene expression data can provide evidence about character identity. This approach has been successfully used to assess cell-type identity. Here we use transcriptomic data to address a long-standing uncertainty in evolutionary biology, the identity of avian wing digits. Embryological evidence clearly identifies the three wing digits as developing from digit positions 2, 3 and 4 (ref. 6), whereas palaeontological data suggest that they are digits I, II and III. We compare the transcriptomes of the wing and foot digits and find a strong signal that unites the first wing digit with the first foot digit, even though the first wing digit develops from embryological position 2. Interestingly, our transcriptomic data of the posterior digits show a higher degree of differentiation among forelimb digits compared with hindlimb digits. These data show that in the stem lineage of birds the first digit underwent a translocation from digit position 1 to position 2, and further indicate that the posterior wing digits have unique identities contrary to any model of avian digit identity proposed so far.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.