ArticleNature nanotechnology2011
Gold nanoparticles for high-throughput genotyping of long-range haplotypes.
Article in Nature nanotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 113 citations in OpenAlex.
- The nucleic acid reactions on the nanomaterials surface for biomedicine.Journal of nanobiotechnology · 2025Review
- Nucleic Acid Framework-Enabled Spatial Organization for Biological Applications.Chem & bio engineering · 2025Review
- Molecular Weights of Polyethyleneimine-Dependent Physicochemical Tuning of Gold Nanoparticles and FRET-Based Turn-On Sensing of Polymyxin B.Sensors (Basel, Switzerland) · 2024Article
- Single-Molecule Nanomechanical Genotyping with DNA Origami-Based Shape IDs.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Development and Evaluation of NanoPCR for the Detection of Goose Parvovirus.Veterinary sciences · 2022Article
- MoSBioactive materials · 2021Review
- Taqman-MGB nanoPCR for Highly Specific Detection of Single-Base Mutations.International journal of nanomedicine · 2021Article
- Effects of graphene oxide on PCR amplification for microbial community survey.BMC microbiology · 2020Article
- Locus-patterned sequence oriented enrichment for multi-dimensional gene analysis.Chemical science · 2019Article
- Gold nanoflower-based surface-enhanced Raman probes for pH mapping of tumor cell microenviroment.Cell proliferation · 2019Article
- Enhancement of the polymerase chain reaction by tungsten disulfide.RSC advances · 2019Article
- Article
- Programming DNA origami assembly for shape-resolved nanomechanical imaging labels.Nature protocols · 2018Article
- Development of gold nanoparticles biosensor for ultrasensitive diagnosis of foot and mouth disease virus.Journal of nanobiotechnology · 2018Article
- DNA origami-based shape IDs for single-molecule nanomechanical genotyping.Nature communications · 2017Article
- Quantitative investigation of the poly-adenine DNA dissociation from the surface of gold nanoparticles.Scientific reports · 2015Article
- Chemical basis of interactions between engineered nanoparticles and biological systems.Chemical reviews · 2014Review
- Avatar DNA nanohybrid system in chip-on-a-phone.Scientific reports · 2014Article
- CdTe quantum dots enhance feasibility of EvaGreen-based real-time PCR with decent amplification fidelity.Molecular biotechnology · 2013Article
- Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Completion of the Human Genome Project and the HapMap Project has led to increasing demands for mapping complex traits in humans to understand the aetiology of diseases. Identifying variations in the DNA sequence, which affect how we develop disease and respond to pathogens and drugs, is important for this purpose, but it is difficult to identify these variations in large sample sets. Here we show that through a combination of capillary sequencing and polymerase chain reaction assisted by gold nanoparticles, it is possible to identify several DNA variations that are associated with age-related macular degeneration and psoriasis on significant regions of human genomic DNA. Our method is accurate and promising for large-scale and high-throughput genetic analysis of susceptibility towards disease and drug resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.