Evidence map›Paper›PMID 21892143›Full record

ArticleNature cell biology2011

Wnt: what's needed to maintain pluripotency?

Hitoshi Niwa

Abstract readNewsComment
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Prognostic implication of SOX2 expression in small intestinal adenocarcinoma.Virchows Archiv : an international journal of pathology · 2021
    Article
  3. Review
  4. Article
  5. Article
  6. Noise-processing by signaling networks.Scientific reports · 2017
    Article
  7. A chemical approach to myocardial protection and regeneration.European heart journal supplements : journal of the European Society of Cardiology · 2016
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Direct reprogramming of adult cells: avoiding the pluripotent state.Stem cells and cloning : advances and applications · 2014
    Review
  15. Review
  16. Inhibition of androgen receptor and β-catenin activity in prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  17. Signaling networks in human pluripotent stem cells.Current opinion in cell biology · 2013
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Hitoshi Niwa

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A precise role for the canonical Wnt pathway in maintaining pluripotency in mouse embryonic stem cells (mESCs) has been debated. Four recent reports add pieces to the puzzle and together these results may help establish a robust model.

Indexed as

Cell MovementCell ProliferationSignal TransductionAnimalsBasic Helix-Loop-Helix Proteinsbeta CateninCell DifferentiationEmbryonic Stem CellsFemaleGerm LayersGlycogen Synthase Kinase 3Hepatocyte Nuclear Factor 1-alphaPluripotent Stem CellsProtein Kinase InhibitorsStem CellsWnt3A ProteinBasic Helix-Loop-Helix Proteinsbeta CateninGlycogen Synthase Kinase 3Hepatocyte Nuclear Factor 1-alphaProtein Kinase InhibitorsWnt3A ProteinWnt3a protein, mouseWnt Proteins

Identifiers

PMID21892143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.