Evidence map›Paper›PMID 21892142›Full record

ReviewNature cell biology2011

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.

Maria M Mihaylova, Reuben J Shaw

Open access · greenAbstract readReview
In one paragraph

Review in Nature cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,698 papers.

0numbers the graph read from it
0cells of the map it votes in
1,698citing papers in PubMed
47.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,698 citing papers in PubMed, 2,884 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Cancers · 2026
    Review
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  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Autophagy in Melanoma: Molecular Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2026
    Review
  17. Article
  18. Review
  19. Article
  20. Study on the Effects and Mechanisms of Resveratrol in Improving Cognitive Impairment in AβJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article

1,638 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Maria M MihaylovaMolecular & Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Reuben J Shaw
Howard Hughes Medical Institute · USSalk Institute for Biological Studies · US

Funding

Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
Role of LKB1 and AMPK in Metformin and TZD Control of Glucose Metabolism in LiverR01DK080425 · NIDDK · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHAW, REUBEN · 2007 to 2015
$3.6M
Howard Hughes Medical InstituteNCI NIH HHS 1P01CA120964NCI NIH HHS P01 CA120964NIDDK NIH HHS R01 DK080425
6 · The paper itself

Abstract

One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. Here we review a number of recent breakthroughs in the mechanistic understanding of AMPK function, focusing on a number of newly identified downstream effectors of AMPK.

Indexed as

Cell ProliferationAMP-Activated Protein KinasesAnimalsAutophagyCell PolarityEukaryotaHumansModels, BiologicalProtein SubunitsSignal TransductionAMP-Activated Protein KinasesProtein Subunits

Identifiers

PMID21892142
PMCPMC3249400
OpenAlexW2079580613

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.