ArticlePhysics in medicine and biology2011
Predictive models for pressure-driven fluid infusions into brain parenchyma.
Article in Physics in medicine and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- MR-Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures.Journal of magnetic resonance imaging : JMRI · 2025Review
- Effect of infusion direction on convection-enhanced drug delivery to anisotropic tissue.Journal of the Royal Society, Interface · 2024Article
- Article
- Role of Tissue Hydraulic Permeability in Convection-Enhanced Delivery of Nanoparticle-Encapsulated Chemotherapy Drugs to Brain Tumour.Pharmaceutical research · 2022Article
- Insights into Infusion-Based Targeted Drug Delivery in the Brain: Perspectives, Challenges and Opportunities.International journal of molecular sciences · 2022Review
- Convection-Enhanced DeliveryFrontiers in bioengineering and biotechnology · 2022Article
- Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers.Drug delivery and translational research · 2021Article
- On the microstructural origin of brain white matter hydraulic permeability.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Integrating Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging to Improve the Predictive Capabilities of CED Models.Annals of biomedical engineering · 2021Article
- Determinants of Intraparenchymal Infusion Distributions: Modeling and Analyses of Human Glioblastoma Trials.Pharmaceutics · 2020Article
- Methods to measure, model and manipulate fluid flow in brain.Journal of neuroscience methods · 2020Review
- Improving the Prediction of Local Drug Distribution Profiles in the Brain with a New 2D Mathematical Model.Bulletin of mathematical biology · 2019Article
- A computational fluid dynamics approach to determine white matter permeability.Biomechanics and modeling in mechanobiology · 2019Article
- The need for mathematical modelling of spatial drug distribution within the brain.Fluids and barriers of the CNS · 2019Review
- FCNN-based axon segmentation for convection-enhanced delivery optimization.International journal of computer assisted radiology and surgery · 2019Article
- Convection-Enhanced Delivery: Connection to and Impact of Interstitial Fluid Flow.Frontiers in oncology · 2019Review
- Theory for acoustic streaming in soft porous matter and its applications to ultrasound-enhanced convective delivery.Journal of therapeutic ultrasound · 2018Article
- Improving the Predictions of Computational Models of Convection-Enhanced Drug Delivery by Accounting for Diffusion Non-gaussianity.Frontiers in neurology · 2018Article
- Nanomaterials for convection-enhanced delivery of agents to treat brain tumors.Current opinion in biomedical engineering · 2017Article
- A model for optimizing delivery of targeted radionuclide therapies into resection cavity margins for the treatment of primary brain cancers.Biomedical physics & engineering express · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Direct infusions into brain parenchyma of biological therapeutics for serious brain diseases have been, and are being, considered. However, individual brains, as well as distinct cytoarchitectural regions within brains, vary in their response to fluid flow and pressure. Further, the tissue responds dynamically to these stimuli, requiring a nonlinear treatment of equations that would describe fluid flow and drug transport in brain. We here report in detail on an individual-specific model and a comparison of its prediction with simulations for living porcine brains. Two critical features we introduced into our model-absent from previous ones, but requirements for any useful simulation-are the infusion-induced interstitial expansion and the backflow. These are significant determinants of the flow. Another feature of our treatment is the use of cross-property relations to obtain individual-specific parameters that are coefficients in the equations. The quantitative results are at least encouraging, showing a high fraction of overlap between the computed and measured volumes of distribution of a tracer molecule and are potentially clinically useful. Several improvements are called for; principally a treatment of the interstitial expansion more fundamentally based on poroelasticity and a better delineation of the diffusion tensor of a particle confined to the interstitial spaces.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.