Evidence map›Paper›PMID 21890745›Full record

ArticleSchizophrenia bulletin2012

Perceptual measurement in schizophrenia: promising electrophysiology and neuroimaging paradigms from CNTRICS.

Pamela D Butler, Yue Chen, Judith M Ford, Mark A Geyer, Steven M Silverstein, Michael F Green

Abstract readConsensus Statement
In one paragraph

Article in Schizophrenia bulletin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pamela D ButlerNathan Kline Institute for Psychiatric Research, Schizophrenia Research Center, Orangeburg, NY, USA. butler@nki.rfmh.org
Yue Chen
Judith M Ford
Mark A Geyer
Steven M Silverstein
Michael F Green

Funding

SENSORY GATING &HABITUATION IN SCHIZOPHRENIAR01MH042228 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 1987 to 2015
$6.5M
EARLY VISUAL PROCESSING IN SCHIZOPHRENIAR01MH043292 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, MICHAEL F. · 1996 to 2010
$3.5M
Cognitive Neurocomputational Task Reliability & Clinical Applications ConsortiumR01MH084828 · NIMH · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI SILVERSTEIN, STEVEN M · 2008 to 2024
$3.3M
DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIAR01MH052885 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GEYER, MARK A · 1995 to 2010
$2.7M
MOTION PROCESSING SYSTEM IN SCHIZOPHRENIAR01MH061824 · NIMH · MC LEAN HOSPITAL (BELMONT, MA) · PI CHEN, YUE · 2000 to 2009
$2.2M
Methods for Sensory Assessment in SchizophreniaR01MH084848 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KAHN, PAMELA BUTLER · 2008 to 2011
$1.5M
Neurobiology of response monitoring failure in schizophreniaK02MH067967 · NIMH · YALE UNIVERSITY · PI FORD, JUDITH M · 2003 to 2010
$1.1M
EARLY VISUAL PROCESSING IN SCHIZOPHRENIAR29MH043292 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, MICHAEL F · 1988 to 1992
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NIMH NIH HHS MH043292NIMH NIH HHS MH052885NIMH NIH HHS MH067967NIMH NIH HHS MH084828NIMH NIH HHS MH58262NIMH NIH HHS MH61824NIMH NIH HHS MH84848NIMH NIH HHS R01 MH042228
6 · The paper itself

Abstract

The sixth meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) focused on selecting promising imaging paradigms for each of the cognitive constructs selected in the first CNTRICS meeting. In the domain of perception, the 2 constructs of interest were "gain control" and "visual integration." CNTRICS received 6 task nominations for imaging paradigms for gain control and 3 task nominations for integration. The breakout group for perception evaluated the degree to which each of these tasks met prespecified criteria. For gain control, the breakout group believed that one task (mismatch negativity) was already mature and was being incorporated into multisite clinical trials. The breakout group recommended that 1 visual task (steady-state visual evoked potentials to magnocellular- vs parvocellular-biased stimuli) and 2 auditory measures (an event-related potential (ERP) measure of corollary discharge and a functional magnetic resonance imaging (fMRI) version of prepulse inhibition of startle) be adapted for use in clinical trials in schizophrenia research. For visual integration, the breakout group recommended that fMRI and ERP versions of a contour integration test and an fMRI version of a coherent motion test be adapted for use in clinical trials. This manuscript describes the ways in which each of these tasks met the criteria used in the breakout group to evaluate and recommend tasks for further development.

Indexed as

Evoked Potentials, AuditoryEvoked Potentials, VisualHumansMagnetic Resonance ImagingPerceptionPsychometricsSchizophrenia

Identifiers

PMID21890745
PMCPMC3245585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.