Evidence map›Paper›PMID 21890640›Full record

ReviewCold Spring Harbor symposia on quantitative biology2011

Gamete formation resets the aging clock in yeast.

E Ünal, A Amon

Abstract readReview
In one paragraph

Review in Cold Spring Harbor symposia on quantitative biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. The life of [PSI].Current genetics · 2018
    Review
  8. Review
  9. Article
  10. A budding yeast's perspective on aging: the shape I'm in.Experimental biology and medicine (Maywood, N.J.) · 2015
    Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

E ÜnalDavid H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
A Amon

Funding

REGULATION OF THE MEIOTIC CELL CYCLER01GM062207 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI AMON, ANGELIKA B · 2001 to 2016
$3.8M
REGULATION OF MITOSIS BY PROTEOLYSIS IN YEASTR29GM056800 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI AMON, ANGELIKA B · 1997 to 2003
$738k
Howard Hughes Medical InstituteNIGMS NIH HHS GM62207NIGMS NIH HHS R01 GM062207NIGMS NIH HHS R29 GM056800
6 · The paper itself

Abstract

Gametogenesis is a process whereby a germ cell differentiates into haploid gametes. We found that, in budding yeast, replicatively aged cells remove age-induced cellular damage during gametogenesis. Importantly, gametes of aged cells have the same replicative potential as those derived from young cells, indicating that life span resets during gametogenesis. Here, we explore the potential mechanisms responsible for gametogenesis-induced rejuvenation and discuss putative analogous mechanisms in higher eukaryotes.

Indexed as

Biological ClocksGerm CellsSaccharomyces cerevisiaeTime Factors

Identifiers

PMID21890640
PMCPMC3912942

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.