ArticleThe Journal of biological chemistry2011
The regulator of calcineurin 1 (RCAN1/DSCR1) activates the cAMP response element-binding protein (CREB) pathway.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- A repressive regulatory cascade shapes temporal patterning of activity-regulated gene expression in a defined sensory neuron type.bioRxiv : the preprint server for biology · 2026Article
- HIV-1 gp120 protein promotes HAND through the calcineurin pathway activation.Mitochondrion · 2023Article
- Cynanoside F Controls Skin Inflammation by Suppressing Mitogen-Activated Protein Kinase Activation.Antioxidants (Basel, Switzerland) · 2022Article
- Article
- CaCells · 2021Review
- Down Syndrome Critical Region 1 Reduces Oxidative Stress-Induced Retinal Ganglion Cells Apoptosis via CREB-Bcl-2 Pathway.Investigative ophthalmology & visual science · 2020Article
- Gene-environment regulatory circuits of right ventricular pathology in tetralogy of fallot.Journal of molecular medicine (Berlin, Germany) · 2019Article
- High-Amplitude Circadian Rhythms inGenetics · 2018Article
- RCAN1 Mutation and Functional Characterization in Children with Sporadic Congenital Heart Disease.Pediatric cardiology · 2018Article
- Article
- Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways.PloS one · 2018Article
- Endothelial Regulator of Calcineurin 1 Promotes Barrier Integrity and Modulates Histamine-Induced Barrier Dysfunction in Anaphylaxis.Frontiers in immunology · 2017Article
- Leucine-Rich Repeat Kinase 2 (LRRK2) Stimulates IL-1β-Mediated Inflammatory Signaling through Phosphorylation of RCAN1.Frontiers in cellular neuroscience · 2017Article
- Commonality in Down and fetal alcohol syndromes.Birth defects research. Part A, Clinical and molecular teratology · 2013Article
- RCAN1 is an important mediator of glucocorticoid-induced apoptosis in human leukemic cells.PloS one · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
cAMP response element-binding protein (CREB) is one of the best known transcription factors in the development and function of the nervous system. In this report, we found that the regulator of calcineurin 1 (RCAN1), which is overexpressed in the brain of patients with Down syndrome, increased the phosphorylation of CREB and cAMP response element-mediated gene transcription in response to the activation of the intracellular cAMP pathway. Furthermore, we found that the increased activation of CREB signaling by RCAN1 depended on the ability of RCAN1 to inhibit calcineurin activity. Our data provide the first evidence that RCAN1 acts as an important regulatory component in the control of CREB signaling.
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