Trial reportJournal of neurology, neurosurgery, and psychiatry2012
Deep brain stimulation in early stage Parkinson's disease: operative experience from a prospective randomised clinical trial.
Trial report in Journal of neurology, neurosurgery, and psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Pooled it
- Connectivity Profile for Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson Disease.Annals of neurology · 2023Trial
- Trial
- Subthalamic Nucleus Deep Brain Stimulation Alters Prefrontal Correlates of Emotion Induction.Neuromodulation : journal of the International Neuromodulation Society · 2017Trial
- Subthalamic nucleus deep brain stimulation in early stage Parkinson's disease.Parkinsonism & related disorders · 2014Trial
- Pilot study assessing the feasibility of applying bilateral subthalamic nucleus deep brain stimulation in very early stage Parkinson's disease: study design and rationale.Journal of Parkinson's disease · 2012Trial
- Theta and beta power in the subthalamic nucleus responds to conflict across subregions and hemispheres.Brain communications · 2025Article
- Article
- Eleven-Year Outcomes of Deep Brain Stimulation in Early-Stage Parkinson Disease.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Development and Validation of a Plasma FAM19A5 and MRI-Based Radiomics Model for Prediction of Parkinson's Disease and Parkinson's Disease With Depression.Frontiers in neuroscience · 2021Article
- Pre-dopa Deep Brain Stimulation: Is Early Deep Brain Stimulation Able to Modify the Natural Course of Parkinson's Disease?Frontiers in neuroscience · 2020Article
- Multi-modal imaging with specialized sequences improves accuracy of the automated subcortical grey matter segmentation.Magnetic resonance imaging · 2019Article
- Anatomical accuracy of standard-practice tractography algorithms in the motor system - A histological validation in the squirrel monkey brain.Magnetic resonance imaging · 2019Article
- Overexpression of microRNA-183 promotes apoptosis of substantia nigra neurons via the inhibition of OSMR in a mouse model of Parkinson's disease.International journal of molecular medicine · 2019Article
- Multi-Modal and Targeted Imaging Improves Automated Mid-Brain Segmentation.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
- Article
- Mechanisms of deep brain stimulation.Journal of neurophysiology · 2016Review
- Proceedings of the Second Annual Deep Brain Stimulation Think Tank: What's in the Pipeline.The International journal of neuroscience · 2015Review
- Article
- Calcium imaging of infrared-stimulated activity in rodent brain.Cell calcium · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRecent evidence suggests that deep brain stimulation of the subthalamic nucleus (STN-DBS) may have a disease modifying effect in early Parkinson's disease (PD). A randomised, prospective study is underway to determine whether STN-DBS in early PD is safe and tolerable. OBJECTIVES/
methods15 of 30 early PD patients were randomised to receive STN-DBS implants in an institutional review board approved protocol. Operative technique, location of DBS leads and perioperative adverse events are reported. Active contact used for stimulation in these patients was compared with 47 advanced PD patients undergoing an identical procedure by the same surgeon.
results14 of the 15 patients did not sustain any long term (>3 months) complications from the surgery. One subject suffered a stroke resulting in mild cognitive changes and slight right arm and face weakness. The average optimal contact used in symptomatic treatment of early PD patients was: anterior -1.1±1.7 mm, lateral 10.7±1.7 mm and superior -3.3±2.5 mm (anterior and posterior commissure coordinates). This location is statistically no different (0.77 mm, p>0.05) than the optimal contact used in the treatment of 47 advanced PD patients.
conclusionsThe perioperative adverse events in this trial of subjects with early stage PD are comparable with those reported for STN-DBS in advanced PD. The active contact position used in early PD is not significantly different from that used in late stage disease. This is the first report of the operative experience from a randomised, surgical versus best medical therapy trial for the early treatment of PD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.