ReviewHuman molecular genetics2011
Multi-ethnic studies in complex traits.
Review in Human molecular genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Meta-Analysis of the Transferability of Bone Mineral Density Genetic Loci Associations From European to African Ancestry Populations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Pooled it
- Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant.Human molecular genetics · 2014Pooled it
- Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT).Molecular psychiatry · 2014Pooled it
- An integrative association analysis for complex diseases in underrepresented groups by leveraging the trans-ethnic genetic similarity.Briefings in bioinformatics · 2026Article
- Evaluating significance of European-associated index SNPs in the East Asian population for 31 complex phenotypes.BMC genomics · 2023Article
- Similarity and diversity of genetic architecture for complex traits between East Asian and European populations.BMC genomics · 2023Article
- Inorganic Pyrophosphate Plasma Levels Are Decreased in Pseudoxanthoma Elasticum Patients and Heterozygous Carriers but Do Not Correlate with the Genotype or Phenotype.Journal of clinical medicine · 2023Article
- Detecting associated genes for complex traits shared across East Asian and European populations under the framework of composite null hypothesis testing.Journal of translational medicine · 2022Article
- Multivariate genome-wide association study of depression, cognition, and memory phenotypes and validation analysis identify 12 cross-ethnic variants.Translational psychiatry · 2022Article
- Article
- Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study.Genome medicine · 2021Article
- Quantifying genetic heterogeneity between continental populations for human height and body mass index.Scientific reports · 2021Article
- Comparison of multiple imputation algorithms and verification using whole-genome sequencing in the CMUH genetic biobank.BioMedicine · 2021Article
- [Trans-ethnic analysis of susceptibility variants in IgA nephropathy].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- The effects of cortisol and adrenal androgen on bone mass in Asians with and without subclinical hypercortisolism.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- The association of cortisol and adrenal androgen with trabecular bone score in patients with adrenal incidentaloma with and without autonomous cortisol secretion.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Observational
- Replicability and Prediction: Lessons and Challenges from GWAS.Trends in genetics : TIG · 2018Review
- Characteristics of Adrenal Incidentalomas in a Large, Prospective Computed Tomography-Based Multicenter Study: The COAR Study in Korea.Yonsei medical journal · 2018Observational
- SNP-SNP interactions between WNT4 and WNT5A were associated with obesity related traits in Han Chinese Population.Scientific reports · 2017Article
- Evaluation of 10 SLE susceptibility loci in Asian populations, which were initially identified in European populations.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The successes of genome-wide association (GWA) studies have mainly come from studies performed in populations of European descent. Since complex traits are characterized by marked genetic heterogeneity, the findings so far may provide an incomplete picture of the genetic architecture of complex traits. However, the recent GWA studies performed on East Asian populations now allow us to globally assess the heterogeneity of association signals between populations of European ancestry and East Asians, and the possible obstacles for multi-ethnic GWA studies. We focused on four different traits that represent a broad range of complex phenotypes, which have been studied in both Europeans and East Asians: type 2 diabetes, systemic lupus erythematosus, ulcerative colitis and height. For each trait, we observed that most of the risk loci identified in East Asians were shared with Europeans. However, we also observed that a significant part of the association signals at these shared loci seems to be independent between populations. This suggests that disease aetiology is common between populations, but that risk variants are often population specific. These variants could be truly population specific and result from natural selection, genetic drift and recent mutations, or they could be spurious, caused by the limitations of the method of analysis employed in the GWA studies. We therefore propose a three-stage framework for multi-ethnic GWA analyses, starting with the commonly used single-nucleotide polymorphism-based analysis, and followed by a gene-based approach and a pathway-based analysis, which will take into account the heterogeneity of association between populations at different levels.
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