ArticleApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine2012
The radiolabeling of proteins by the [18F]AlF method.
Article in Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- SuFEx and macrocyclic chelation define orthogonal reactivity domains enabling isotopically versatile radiopharmaceuticals from a single peptide precursor.bioRxiv : the preprint server for biology · 2026Article
- Diagnostic value of [Frontiers in oncology · 2026Article
- Optimized method for fluorine-18 radiolabeling of Affibody molecules using RESCA.EJNMMI radiopharmacy and chemistry · 2024Article
- Sortase-Mediated Site-Specific Conjugation to Prepare Fluorine-18-Labeled Nanobodies.Bioconjugate chemistry · 2024Article
- Evaluation of [Pharmaceutics · 2023Article
- Development of brain-penetrable antibody radioligands forFrontiers in nuclear medicine · 2023Article
- Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA)Pharmaceuticals (Basel, Switzerland) · 2021Review
- Reaction of [Frontiers in chemistry · 2021Review
- ImmunoPET: Concept, Design, and Applications.Chemical reviews · 2020Review
- A Comprehensive Review of Non-Covalent Radiofluorination Approaches Using Aluminum [Molecules (Basel, Switzerland) · 2019Review
- Article
- Direct fluorine-18 labeling of heat-sensitive biomolecules for positron emission tomography imaging using the AlNature protocols · 2018Article
- Review
- Radiofluorination of a NHC-PFChemical communications (Cambridge, England) · 2017Article
- AlTheranostics · 2017Article
- A pilot study imaging integrin αvβ3 with RGD PET/CT in suspected lung cancer patients.European journal of nuclear medicine and molecular imaging · 2015Article
- Radiofluorination of PSMA-HBED via Al(18)F(2+) Chelation and Biological Evaluations In Vitro.Molecular imaging and biology · 2015Article
- In vivo imaging with antibodies and engineered fragments.Molecular immunology · 2015Review
- Fluorine-18 radiochemistry, labeling strategies and synthetic routes.Bioconjugate chemistry · 2015Review
- Pretargeted imaging and radioimmunotherapy of cancer using antibodies and bioorthogonal chemistry.Frontiers in medicine · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A new ([(18)F]AlF)(2+)-binding ligand that contains 1,4,7-triazacyclononane-1,4-diacetate (NODA) attached to a methyl phenylacetic acid group (MPA) was conjugated to N-(2-aminoethyl)maleimide (EM) to form NODA-MPAEM. The NODA-MPAEM was labeled with ([(18)F]AlF)(2+) at 105°C in 49-82% yield and conjugated at room temperature to an antibody Fab' fragment in 69-80% yield (total time ∼50min) and with retention of immunoreactivity. These data indicate that the rapid and simple [(18)F]AlF-labeling method can be easily adapted for preparing heat-sensitive compounds with (18)F quickly and in high yields.
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Registered trials
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