Evidence map›Paper›PMID 21890053›Full record

ArticleLancet (London, England)2011

Persistence of multiple illnesses in World Trade Center rescue and recovery workers: a cohort study.

Juan P Wisnivesky, Susan L Teitelbaum, Andrew C Todd, Paolo Boffetta, Michael Crane, Laura Crowley, Rafael E de la Hoz, Cornelia Dellenbaugh, Denise Harrison, Robin Herbert and 18 more

Registry-linked trialAbstract read
In one paragraph

Article in Lancet (London, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02246101 (Renal and Cardiovascular Impairment in WTC Responders), which is not on this map. Cited by 165 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02246101 completednot on this mapstarted 2014, after this paper: background citation

Renal and Cardiovascular Impairment in WTC Responders: Implications for Diagnosis and Treatment

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2014 to 2016Enrolled406ConditionsCardiac Disease, Cardiopulmonary Disease, Renal Disease, Cardiovascular Disease
3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Juan P WisniveskyDivisions of General Internal Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. juan.wisnivesky@mssm.edu
Susan L Teitelbaum
Andrew C Todd
Paolo Boffetta
Michael Crane
Laura Crowley
Rafael E de la Hoz
Cornelia Dellenbaugh
Denise Harrison
Robin Herbert
Hyun Kim
Yunho Jeon
Julia Kaplan
Craig Katz
Stephen Levin
Ben Luft
Steven Markowitz
Jacqueline M Moline
Fatih Ozbay
Robert H Pietrzak
Moshe Shapiro
Vansh Sharma
Gwen Skloot
Steven Southwick
Lori A Stevenson
Iris Udasin
Sylvan Wallenstein
Philip J Landrigan

Funding

WTC RHC Data and Coordination CenterU10OH008232 · OH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI LANDRIGAN, PHILIP J · 2004 to 2010
$26.1M
NIOSH CDC HHS 5U10 OH008232NIOSH CDC HHS HHSD200200200384C
6 · The paper itself

Abstract

backgroundMore than 50,000 people participated in the rescue and recovery work that followed the Sept 11, 2001 (9/11) attacks on the World Trade Center (WTC). Multiple health problems in these workers were reported in the early years after the disaster. We report incidence and prevalence rates of physical and mental health disorders during the 9 years since the attacks, examine their associations with occupational exposures, and quantify physical and mental health comorbidities.

methodsIn this longitudinal study of a large cohort of WTC rescue and recovery workers, we gathered data from 27,449 participants in the WTC Screening, Monitoring, and Treatment Program. The study population included police officers, firefighters, construction workers, and municipal workers. We used the Kaplan-Meier procedure to estimate cumulative and annual incidence of physical disorders (asthma, sinusitis, and gastro-oesophageal reflux disease), mental health disorders (depression, post-traumatic stress disorder [PTSD], and panic disorder), and spirometric abnormalities. Incidence rates were assessed also by level of exposure (days worked at the WTC site and exposure to the dust cloud).

findings9-year cumulative incidence of asthma was 27·6% (number at risk: 7027), sinusitis 42·3% (5870), and gastro-oesophageal reflux disease 39·3% (5650). In police officers, cumulative incidence of depression was 7·0% (number at risk: 3648), PTSD 9·3% (3761), and panic disorder 8·4% (3780). In other rescue and recovery workers, cumulative incidence of depression was 27·5% (number at risk: 4200), PTSD 31·9% (4342), and panic disorder 21·2% (4953). 9-year cumulative incidence for spirometric abnormalities was 41·8% (number at risk: 5769); three-quarters of these abnormalities were low forced vital capacity. Incidence of most disorders was highest in workers with greatest WTC exposure. Extensive comorbidity was reported within and between physical and mental health disorders.

interpretation9 years after the 9/11 WTC attacks, rescue and recovery workers continue to have a substantial burden of physical and mental health problems. These findings emphasise the need for continued monitoring and treatment of the WTC rescue and recovery population.

fundingCenters for Disease Control and Prevention and National Institute for Occupational Safety and Health.

Indexed as

MorbidityRescue WorkSeptember 11 Terrorist AttacksAdultAir PollutionAsthmaCohort StudiesDepressionDustFemaleGastroesophageal RefluxHumansMaleMental HealthNew York CityPanic DisorderDust

Identifiers

PMID21890053
PMCPMC9453925

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.