Evidence map›Paper›PMID 21890014›Full record

ReviewClinics in perinatology2011

The contribution of maternal stress to preterm birth: issues and considerations.

Pathik D Wadhwa, Sonja Entringer, Claudia Buss, Michael C Lu

Registry-linked trialAbstract readReview
In one paragraph

Review in Clinics in perinatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06915428 (Personalized Toolkit Building a Comprehensive Approach to Resource Optimization and Empowerment in Pregnancy & Beyond), which is not on this map. Cited by 241 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
241citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06915428 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Personalized Toolkit Building a Comprehensive Approach to Resource Optimization and Empowerment in Pregnancy & Beyond (PTBCARE+) A Randomized Controlled Trial (RCT) of Personalized Care for Prenatal Stress Reduction and Preterm Birth Disparities Prevention

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2026 to 2029Enrolled1,228ConditionsPreterm Birth Complication, Preterm Birth, Preterm Birth Recurrence, PreeclampsiaArmsCare coordination, Electronic massage, support gift #1, Support gift #2, Support gift #3
3 · Its place in the literature

Who cites it

241 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Risks to the Unborn: An Umbrella Review on the Effects of Prenatal Maternal Stress Caused by Natural Disasters.Stress and health : journal of the International Society for the Investigation of Stress · 2025
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181 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pathik D WadhwaDepartments of Psychiatry & Human Behavior, Obstetrics & Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, 3177 Gillespie Neuroscience Research Facility, Irvine, CA 92697, USA. pwadhwa@uci.edu
Sonja Entringer
Claudia Buss
Michael C Lu

Funding

PROJECT I POPULATION STRUCTURE OF GENETIC VARIATION IN PREGNANCYP01HD047609 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2005 to 2009
$4.9M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
FETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAINR01MH091351 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, WADHWA, PATHIK D · 2011 to 2015
$3.3M
Prenatal stress biology, infant body composition and obesity riskR01HD065825 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2010 to 2014
$2.2M
NICHD NIH HHS P01 HD-047609NICHD NIH HHS P01 HD047609NICHD NIH HHS R01 HD-060628NICHD NIH HHS R01 HD060628NICHD NIH HHS R01 HD-065825NICHD NIH HHS R01 HD065825NIMH NIH HHS R01 MH-091351NIMH NIH HHS R01 MH091351
6 · The paper itself

Abstract

Preterm birth represents the most significant problem in maternal-child health, with maternal stress identified as a variable of interest. The effects of maternal stress on risk of preterm birth may vary as a function of context. This article focuses on select key issues and questions highlighting the need to develop a better understanding of which particular subgroups of pregnant women may be especially vulnerable to the potentially detrimental effects of maternal stress, and under what circumstances and at which stages of gestation. Issues related to the characterization and assessment of maternal stress and candidate biologic mechanisms are addressed.

Indexed as

Infant, PrematureStress, PsychologicalFemaleHumansInfant, NewbornInfant, Premature, DiseasesMothersObstetric Labor, PrematurePregnancyPregnancy ComplicationsPremature BirthUnited States

Identifiers

PMID21890014
PMCPMC3179976

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.