Evidence map›Paper›PMID 21889889›Full record

ReviewCurrent opinion in structural biology2011

Emerging themes in cryptococcal capsule synthesis.

Pardeep Kumar, Meng Yang, Brian C Haynes, Michael L Skowyra, Tamara L Doering

Abstract readReview
In one paragraph

Review in Current opinion in structural biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A Quick reCAP: DiscoveringJournal of fungi (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. The capsule ofVirulence · 2019
    Review
  11. Review
  12. Peeling the onion: the outer layers of Cryptococcus neoformans.Memorias do Instituto Oswaldo Cruz · 2018
    Review
  13. Article
  14. Biological roles of glycans.Glycobiology · 2017
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pardeep KumarDepartment of Molecular Microbiology, Washington University Medical School, St. Louis, MO 63110, USA.
Meng Yang
Brian C Haynes
Michael L Skowyra
Tamara L Doering

Funding

CAPSULE REGULATION AND VIRULENCE IN CRYPTOCOCCUS NEOFORMANSR01AI087794 · NIAID · WASHINGTON UNIVERSITY · PI BRENT, MICHAEL R, DOERING, TAMARA L · 2011 to 2020
$4.1M
GLYCAN BIOSYNTHESIS IN CRYPTOCOCCUS NEOFORMANSR01GM071007 · NIGMS · WASHINGTON UNIVERSITY · PI DOERING, TAMARA L · 2004 to 2010
$1.9M
NIAID NIH HHS AI087794NIAID NIH HHS R01 AI087794NIGMS NIH HHS GM071007NIGMS NIH HHS R01 GM071007
6 · The paper itself

Abstract

Cryptococcus neoformans, a basidiomycete yeast and opportunistic pathogen, expends significant biosynthetic effort on construction of a polysaccharide capsule with a radius that may be many times that of the cell. Beyond posing a stimulating challenge in terms of defining biosynthetic pathways, the capsule is required for this yeast to cause fatal disease. This combination has focused the attention of researchers on this system. Here we briefly review two aspects of the rapidly advancing field of capsule synthesis: the extensive variation that occurs in capsule polymers and the regulation of capsule biosynthesis.

Indexed as

Gene Expression Regulation, FungalCell MembraneCell WallCryptococcus neoformansFungal ProteinsGene DeletionMicroscopy, ElectronPolymersPolysaccharidesSignal TransductionVirulence FactorsFungal ProteinsglucuronoxylomannanPolymersPolysaccharidesVirulence Factors

Identifiers

PMID21889889
PMCPMC3189294

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.