ReviewEpilepsy research2011
Transition to absence seizures and the role of GABA(A) receptors.
Review in Epilepsy research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Spike-and-wave discharges of absence seizures in a sleep waves-constrained corticothalamic model.CNS neuroscience & therapeutics · 2024Article
- Astrocytes as a target for therapeutic strategies in epilepsy: current insights.Frontiers in molecular neuroscience · 2023Review
- Altered GABAInternational journal of molecular sciences · 2022Article
- Human astrocytes in the diseased brain.Brain research bulletin · 2018Review
- Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy.Neurochemical research · 2017Review
- Generalized seizures in a neural field model with bursting dynamics.Journal of computational neuroscience · 2015Article
- Disinhibition-induced transitions between absence and tonic-clonic epileptic seizures.Scientific reports · 2015Article
- Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases.Molecular pharmacology · 2015Review
- Role of multiple-scale modeling of epilepsy in seizure forecasting.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2015Review
- Delta opioid receptors expressed in forebrain GABAergic neurons are responsible for SNC80-induced seizures.Behavioural brain research · 2015Article
- Animal models of absence epilepsies: what do they model and do sex and sex hormones matter?Neurobiology of disease · 2014Review
- Hidden in plain sight: spike-wave discharges in mouse inbred strains.Genes, brain, and behavior · 2014Article
- Extrasynaptic GABAA receptors in mediodorsal thalamic nucleus modulate fear extinction learning.Molecular brain · 2014Article
- Animal models of epilepsy: use and limitations.Neuropsychiatric disease and treatment · 2014Review
- Modulation of epileptic activity by deep brain stimulation: a model-based study of frequency-dependent effects.Frontiers in computational neuroscience · 2013Article
- Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice.Frontiers in cellular neuroscience · 2013Article
- Typical Spike-and-Wave Activity in Hypoxic-Ischemic Brain Injury and its Implications for Classifying Nonconvulsive Status Epilepticus.Clinical medicine insights. Case reports · 2012Article
- Mom Genes: A Role for Loss of MaternalEpilepsy currentsArticle
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Absence seizures appear to be initiated in a putative cortical 'initiation site' by the expression of medium-amplitude 5-9Hz oscillations, which may in part be due to a decreased phasic GABA(A) receptor function. These oscillations rapidly spread to other cortical areas and to the thalamus, leading to fully developed generalized spike and wave discharges. In thalamocortical neurons of genetic models, phasic GABA(A) inhibition is either unchanged or increased, whereas tonic GABA(A) inhibition is increased both in genetic and pharmacological models. This enhanced tonic inhibition is required for absence seizure generation, and in genetic models it results from a malfunction in the astrocytic GABA transporter GAT-1. Contradictory results from inbred and transgenic animals still do not allow us to draw firm conclusions on changes in phasic GABA(A) inhibition in the GABAergic neurons of the nucleus reticularis thalami. Mathematical modelling may enhance our understanding of these competing hypotheses, by permitting investigations of their mechanistic aspects, hence enabling a greater understanding of the processes underlying seizure generation and evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.