ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2011
Dementia and Alzheimer's disease: a new direction.The 2010 Jay L. Foster Memorial Lecture.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Correlation analysis of peripheral platelet markers and disease phenotypes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Differential Effects of Endocannabinoids on Amyloid-Beta Aggregation and Toxicity.International journal of molecular sciences · 2023Article
- Neurodegenerative Diseases and Cell Reprogramming.Molecular neurobiology · 2020Review
- Precision Medicine in Neurology: The Inspirational Paradigm of Complement Therapeutics.Pharmaceuticals (Basel, Switzerland) · 2020Review
- A new era for dementia epidemiology: Alzheimer's disease, hardening of arteries, or just old age?European journal of epidemiology · 2018Review
- Amyloid β Deposition and Suspected Non-Alzheimer Pathophysiology and Cognitive Decline Patterns for 12 Years in Oldest Old Participants Without Dementia.JAMA neurology · 2018Observational
- The limitations of opportunistic epidemiology, pseudopod epidemiology.European journal of epidemiology · 2016Article
- Risk of dementia and death in the long-term follow-up of the Pittsburgh Cardiovascular Health Study-Cognition Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2016Article
- The Epidemiological Scale of Alzheimer's Disease.Journal of clinical medicine research · 2015Review
- Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord.Scientific reports · 2015Article
- Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease.Frontiers in physiology · 2013Article
- Alzheimer's disease: a clinical practice-oriented review.Frontiers in neurology · 2012Article
- Age, Alzheimer's disease, and the big picture.International psychogeriatrics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe modern era of Alzheimer's disease (AD) research began in the early 1980s with the establishment of AD research centers and expanded research programs at the National Institute on Aging.
methodsOver the past 30 years, there has been success in defining criteria for AD and dementia, association of important genetic disorders related to premature dementia in families, the association of apolipoprotein-E(4), and measurement of incidence and prevalence and selected risk factors. However, prevention and treatment have been elusive.
resultsThe development of new technologies, especially magnetic resonance imaging, positron emission tomography to measure amyloid in vivo in the brain and glucose metabolism, cerebrospinal fluid examination, better genetic markers, large-scale longitudinal epidemiology studies, and preventive clinical trials has rapidly begun a new era of research that offers opportunities to better understand etiology, that is, determinants of amyloid biology in the brain, neurofibrillary tangles, synaptic loss, and dementia.
conclusionsThere are three major hypotheses related to dementia: amyloid deposition and secondary synaptic loss as a unique disease, vascular injury, and "aging." New research must be hypothesis-driven and lead to testable approaches for treatment and prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.