Evidence map›Paper›PMID 21889116›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2011

Neuropsychiatric symptoms in Alzheimer's disease.

Constantine G Lyketsos, Maria C Carrillo, J Michael Ryan, Ara S Khachaturian, Paula Trzepacz, Joan Amatniek, Jesse Cedarbaum, Robert Brashear, David S Miller

Registry-linked trialOpen access · greenAbstract readEditorial
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05477862 (Neural Mechanisms of Induced Calmness After Listening to Improvisatory Music), which is not on this map. Cited by 489 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
489citing papers in PubMed, 3 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05477862 naenrolling by invitationnot on this mapstarted 2023, after this paper: background citation

Neural Mechanisms of Induced Calmness After Listening to Improvisatory Music: An Investigation for Healthy Individuals and Persons With Alzheimer's Dementia

TypeinterventionalSponsorNorthwestern UniversityRan2023 to 2026Enrolled30ConditionsAlzheimer DiseaseArmsClinically Designed Improvisatory Music
3 · Its place in the literature

Who cites it

489 citing papers in PubMed, 3 syntheses or guidelines pooled it, 1,108 citations in OpenAlex.

  1. Efficacy and safety of brexpiprazole for the treatment of agitation in Alzheimer's disease: a meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  11. Psychiatric Hospitalization Precipitants and Outcomes in a Comprehensive Dementia Care Program.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
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  12. Article
  13. Temporal Patterns of BPSD During a Multimodal Non-Pharmacological Intervention in Nursing Home and Daycare Centre Settings.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Article
  14. Toward Precision Neuropsychiatry of Dementia: Neuropsychiatric Symptoms as Multidimensional Clinical Phenotypes.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Review
  15. Cellular transcriptomic signatures underpinning the heterogeneity of depression in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  20. Age-Associated Behavioral Alterations in Laboratory-Housed Octodon degus.bioRxiv : the preprint server for biology · 2026
    Article

429 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Constantine G LyketsosDepartment of Psychiatry, The Johns Hopkins Bayview, Baltimore, MD, USA.
Maria C Carrillo
J Michael Ryan
Ara S Khachaturian
Paula Trzepacz
Joan Amatniek
Jesse Cedarbaum
Robert Brashear
David S Miller
Alzheimer's Association · USBristol-Myers Squibb (United States) · USEli Lilly (United States) · USJanssen (United States) · USJohns Hopkins University · USPfizer (United States) · USSunesis (United States) · US

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
NIA NIH HHS P50 AG005146NIA NIH HHS P50AG005146
6 · The paper itself

Abstract

Neuropsychiatric symptoms (NPS) are core features of Alzheimer's disease and related dementias. Once thought to emerge primarily in people with late-stage disease, these symptoms are currently known to manifest commonly in very early disease and in prodromal phases, such as mild cognitive impairment. Despite decades of research, reliable treatments for dementia-associated NPS have not been found, and those that are in widespread use present notable risks for people using these medications. An Alzheimer's Association Research Roundtable was convened in the spring of 2010 to review what is known about NPS in Alzheimer's disease, to discuss classification and underlying neuropathogenesis and vulnerabilities, and to formulate recommendations for new approaches to tailored therapeutics.

Indexed as

Alzheimer DiseaseCognitive DysfunctionNeurocognitive DisordersAgedAggressionApathyConsensus Statements as TopicDepressive DisorderHumans

Identifiers

PMID21889116
PMCPMC3299979
OpenAlexW2108335346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.