Evidence map›Paper›PMID 21888998›Full record

ArticleBiochimica et biophysica acta2012

Chromatin-mediated Candida albicans virulence.

Jessica Lopes da Rosa, Paul D Kaufman

Abstract read
In one paragraph

Article in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Echinocandin Adaptation inJournal of fungi (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Underlying mechanisms of the effect of minocycline againstExperimental and therapeutic medicine · 2021
    Article
  7. Article
  8. Article
  9. Epigenetic mechanisms of drug resistance in fungi.Fungal genetics and biology : FG & B · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. A small molecule inhibitor of fungal histone acetyltransferase Rtt109.Bioorganic & medicinal chemistry letters · 2013
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jessica Lopes da Rosa
Paul D Kaufman
University of Massachusetts Chan Medical School · US

Funding

Small molecule inhibitors of a Candida albicans histone modifying enzymeF31AI078726 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LOPES DA ROSA-SPIEGLER, JESSICA RAMOS · 2009 to 2012
$94k
NIAID NIH HHS F31 AI078726
6 · The paper itself

Abstract

Candida albicans is the most prevalent human fungal pathogen. To successfully propagate an infection, this organism relies on the ability to change morphology, express virulence-associated genes and resist DNA damage caused by the host immune system. Many of these events involve chromatin alterations that are crucial for virulence. This review will focus on the studies that have been conducted on how chromatin function affects pathogenicity of C. albicans and other fungi. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.

Identifiers

PMID21888998
PMCPMC3243783
OpenAlexW2047431847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.