Evidence for β-nicotinamide adenine dinucleotide as a purinergic, inhibitory neurotransmitter in doubt.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed.

1. β-Nicotinamide adenine dinucleotide (β-NAD) acts as a bronchodilator.PloS one · 2025
   Article
2. β-Nicotinamide adenine dinucleotide acts at prejunctional adenosine A1 receptors to suppress inhibitory musculomotor neurotransmission in guinea pig colon and human jejunum.American journal of physiology. Gastrointestinal and liver physiology · 2015
   Article
3. The purinergic neurotransmitter revisited: a single substance or multiple players?Pharmacology & therapeutics · 2014
   Review
4. Purinergic neuromuscular transmission in the gastrointestinal tract; functional basis for future clinical and pharmacological studies.British journal of pharmacology · 2014
   Review
5. Purinergic signalling in the gastrointestinal tract and related organs in health and disease.Purinergic signalling · 2014
   Review
6. Structure activity relationship of synaptic and junctional neurotransmission.Autonomic neuroscience : basic & clinical · 2013
   Review
7. Progress in understanding of inhibitory purinergic neuromuscular transmission in the gut.Neurogastroenterology and motility · 2013
   Review
8. The roles of purinergic signaling during gastrointestinal inflammation.Current opinion in pharmacology · 2012
   Review
9. Purinergic neuromuscular transmission is absent in the colon of P2Y(1) knocked out mice.The Journal of physiology · 2012
   Article
10. Role of myosin Va in purinergic vesicular neurotransmission in the gut.American journal of physiology. Gastrointestinal and liver physiology · 2012
    Article
11. Nicotinamide adenine dinucleotide replenishment rescues colon degeneration in aged mice.Signal transduction and targeted therapy
    Article

Corrections and comments

• Comment on
  β-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons.2011

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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