ArticleBiology of sex differences2011
Cyclin D1 expression in colorectal cancer is a favorable prognostic factor in men but not in women in a prospective, population-based cohort study.
Article in Biology of sex differences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Association ofGenetics research · 2022Pooled it
- Expression of cyclin D1a and D1b as predictive factors for treatment response in colorectal cancer.British journal of cancer · 2012Trial
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- Cyclin-dependent kinase inhibitors and the treatment of gastrointestinal cancers.The American journal of pathology · 2015Review
- Prognostic significance of cyclin D1 and E-cadherin expression in laryngeal squamous cell carcinoma.Pathology oncology research : POR · 2014Article
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- HMG-CoA reductase expression in primary colorectal cancer correlates with favourable clinicopathological characteristics and an improved clinical outcome.Diagnostic pathology · 2014Article
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- Absence of autophagy-related proteins expression is associated with poor prognosis in patients with colorectal adenocarcinoma.Gastroenterology research and practice · 2014Article
- Influence of anthropometric factors on tumour biological characteristics of colorectal cancer in men and women: a cohort study.Journal of translational medicine · 2013Article
- Research and clinical applications of molecular biomarkers in gastrointestinal carcinoma (Review).Biomedical reports · 2013Article
- Sex differences in the prognostic significance of KRAS codons 12 and 13, and BRAF mutations in colorectal cancer: a cohort study.Biology of sex differences · 2013Article
- Associations of beta-catenin alterations and MSI screening status with expression of key cell cycle regulating proteins and survival from colorectal cancer.Diagnostic pathology · 2013Article
- Gender, anthropometric factors and risk of colorectal cancer with particular reference to tumour location and TNM stage: a cohort study.Biology of sex differences · 2012Article
- Molecular correlates and prognostic significance of SATB1 expression in colorectal cancer.Diagnostic pathology · 2012Article
- Modifying effect of gender on the prognostic value of clinicopathological factors and Ki67 expression in melanoma: a population-based cohort study.Biology of sex differences · 2012Article
- A cohort study of the prognostic and treatment predictive value of SATB2 expression in colorectal cancer.British journal of cancer · 2012Article
- Coffee polyphenols change the expression of STAT5B and ATF-2 modifying cyclin D1 levels in cancer cells.Oxidative medicine and cellular longevity · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough colorectal cancer (CRC) is generally not considered to be a hormone-dependent malignancy, several sex-related differences in incidence, molecular characteristics and survival have been reported. Epidemiological studies have consistently shown that increased exposure to female sex hormones is associated with a lower risk of CRC in women, and cyclin D1, an important downstream effector in estrogen-mediated signaling, is commonly activated in CRC. In this study, we analyzed the prognostic significance of cyclin D1 expression in CRC, with particular reference to sex-related differences, in tumors from a large, prospective, population-based cohort.
methodsUsing tissue microarrays and immunohistochemistry, the fraction and intensity of cyclin D1 expression was evaluated in 527 incident CRC cases from the Malmö Diet and Cancer Study. The χ2 and Spearman's rho (ρ) tests were used for comparison of cyclin D1 expression and relevant clinicopathological characteristics. Kaplan-Meier analysis and Cox proportional hazards modeling were used to assess the effect of cyclin D1 expression on cancer-specific survival (CSS) in univariate and multivariate analysis, adjusted for established prognostic factors.
resultsCyclin D1 intensity was significantly lower in male compared with female CRC (P = 0.018). In the full cohort, cyclin D1 expression was associated with a significantly prolonged CSS (hazard ratio (HR) = 0.69; 95% CI 0.49 to 0.96, P = 0.026) but subgroup analysis according to gender revealed a strongly accentuated prognostic effect of cyclin D1 in male CRC (HR = 0.48; 95% CI 0.31 to 0.74, P < 0.001), which was in contrast to female CRC, where cyclin D1 was not prognostic (HR = 1.05; 95% CI 0.62 to 1.78, P = 0.864) (Pinteraction = 0.024). The prognostic value of cyclin D1 was not retained in multivariate analysis, either in the full cohort or in male CRC.
conclusionsCyclin D1 expression is strongly associated with prolonged survival in male CRC. These findings not only support an important role for cyclin D1 in colorectal carcinogenesis, but also add further weight to the accumulating evidence that CRC is indeed a hormone-dependent malignancy, for which prognostic and treatment-predictive molecular biomarkers should be evaluated differently in women and men.
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