Evidence map›Paper›PMID 21887612›Full record

ReviewCurrent diabetes reports2011

Gene × environment interactions in type 2 diabetes.

Paul W Franks

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current diabetes reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Systematic Review of Polygenic Risk Scores for Type 1 and Type 2 Diabetes.International journal of molecular sciences · 2020
    Pooled it
  2. Pooled it
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  15. Genomics of Particulate Matter Exposure Associated Cardiopulmonary Disease: A Narrative Review.International journal of environmental research and public health · 2019
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Impact of the Polymorphism NearJournal of human kinetics · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Paul W FranksDepartment of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Skåne University Hospital Malmö, 205 02 Malmö, Sweden. paul.franks@med.lu.se

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

People vary genetically in their susceptibility to the effects of environmental risk factors for many diseases. Genetic variation also underlies the extent to which people respond appropriately to clinical therapies. Defining the basis to the interactions between the genome and the environment may help elucidate the biologic basis to diseases such as type 2 diabetes, as well as help target preventive therapies and treatments. This review examines 1) some of the most current evidence on gene × environment interactions in relation to type 2 diabetes; 2) outlines how the availability of information on gene × environment interactions might help improve the prevention and treatment of type 2 diabetes; and 3) discusses existing and emerging strategies that might enhance our ability to detect and exploit gene × environment interactions in complex disease traits.

Indexed as

Gene-Environment InteractionDiabetes Mellitus, Type 2Genetic Predisposition to DiseaseHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.