ArticlePsychopharmacology2012
Unidirectional relationship between heroin self-administration and impulsive decision-making in rats.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Contributions of the interaction between mu-opioid receptors and dopamine receptors in the regulation of risky decision making.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
- Chemogenetic Inhibition and Optogenetic Depotentiation of the Prelimbic Cortex to Paraventricular Thalamus Pathway Attenuate Abstinence-Induced Plasticity and Heroin Seeking in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behaviour.Addiction biology · 2024Article
- Differential effects of acute and prolonged morphine withdrawal on motivational and goal-directed control over reward-seeking behavior.bioRxiv : the preprint server for biology · 2023Article
- Role of preexisting inhibitory control deficits vs. drug use history in mediating insensitivity to aversive consequences in a rat model of polysubstance use.Psychopharmacology · 2022Article
- Preconception paternal morphine exposure leads to an impulsive phenotype in male rat progeny.Psychopharmacology · 2021Article
- Animal Models of the Behavioral Symptoms of Substance Use Disorders.Cold Spring Harbor perspectives in medicine · 2021Review
- Behavioral predictors of individual differences in opioid addiction vulnerability as measured using i.v. self-administration in rats.Drug and alcohol dependence · 2021Review
- Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- The Opioid-Addicted Tetrapartite Synapse.Biological psychiatry · 2020Review
- Ethanol pre-exposure does not increase delay discounting in P rats, but does impair the ability to dynamically adapt behavioral allocation to changing reinforcer contingencies.Pharmacology, biochemistry, and behavior · 2019Article
- Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health.Perspectives on behavior science · 2019Article
- Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway.ACS chemical neuroscience · 2019Review
- Prefrontal-accumbens opioid plasticity: Implications for relapse and dependence.Pharmacological research · 2019Review
- Adolescent morphine exposure induces immediate and long-term increases in impulsive behavior.Psychopharmacology · 2018Article
- Relationship of Probable Attention Deficit Hyperactivity Disorder with Severity of Psychopathology and Impulsivity in a Sample of Male Patients with Opioid Use Disorder.Psychiatry investigation · 2018Article
- Article
- The effects of heroin administration and drug cues on impulsivity.Journal of clinical and experimental neuropsychology · 2016Article
- Impulsivity in abstinent alcohol and polydrug dependence: a multidimensional approach.Psychopharmacology · 2016Article
- Daily morphine administration increases impulsivity in rats responding under a 5-choice serial reaction time task.British journal of pharmacology · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleThere is growing clinical evidence for a strong relationship between drug addiction and impulsivity. However, it is not fully clear whether impulsivity is a pre-existing trait or a consequence of drug abuse. Recent observations in the animal models show that pre-existing levels of impulsivity predict cocaine and nicotine seeking. Whether such relationships also exist with respect to non-stimulant drugs is largely unknown.
objectiveWe studied the relationship between impulsive choice and vulnerability to heroin taking and seeking. MATERIALS AND
methodsRats were selected in the delayed reward task based on individual differences in impulsive choice. Subsequently, heroin intravenous self-administration behaviour was analysed, including acquisition of heroin intake, motivation, extinction and drug- and cue-induced reinstatement. Throughout the entire experiment, changes in impulsive choice were monitored weekly. RESULTS AND DISCUSSION: High impulsivity did not predict measures of heroin taking. Moreover, high impulsive rats did not differ from low impulsive rats in extinction rates or heroin- and cue-induced reinstatement. However, both groups became more impulsive as heroin self-administration continued. During abstinence, impulsivity levels returned towards baseline (pre-heroin) levels. Our results indicate that, in contrast to psychostimulants, impulsive choice does not predict vulnerability to heroin seeking and taking.
conclusionThese data implicate that different neural mechanisms may underlie the vulnerability to opiate and psychostimulant dependence. Moreover, our data suggest that elevated impulsivity levels as observed in heroin-dependent subjects are a consequence of heroin intake rather than a pre-existing vulnerability trait.
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