ArticlePloS one2011
Lymphoid organ-resident dendritic cells exhibit unique transcriptional fingerprints based on subset and site.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative genomics analysis of mononuclear phagocyte subsets confirms homology between lymphoid tissue-resident and dermal XCR1(+) DCs in mouse and human and distinguishes them from Langerhans cells.Journal of immunological methods · 2016Pooled it
- TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription.Cellular & molecular immunology · 2024Article
- The role of retinoic acid in the production of immunoglobulin A.Mucosal immunology · 2022Review
- The thymic microenvironment gradually modulates the phenotype of thymus-homing peripheral conventional dendritic cells.Immunity, inflammation and disease · 2022Article
- Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Molecular mechanisms of dendritic cell migration in immunity and cancer.Medical microbiology and immunology · 2020Review
- Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines.Frontiers in immunology · 2018Review
- Establishment and Characterization of a Functionally Competent Type 2 Conventional Dendritic Cell Line.Frontiers in immunology · 2018Article
- XCR1+ dendritic cells promote memory CD8+ T cell recall upon secondary infections with Listeria monocytogenes or certain viruses.The Journal of experimental medicine · 2016Article
- Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.Nature medicine · 2015Article
- The origins and functions of dendritic cells and macrophages in the skin.Nature reviews. Immunology · 2014Review
- A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells.PloS one · 2014Article
- Self-antigen presentation by dendritic cells in autoimmunity.Frontiers in immunology · 2014Review
- Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells.The Journal of experimental medicine · 2013Article
- Dendritic cell subtypes from lymph nodes and blood show contrasted gene expression programs upon Bluetongue virus infection.Journal of virology · 2013Article
- Re(de)fining the dendritic cell lineage.Nature immunology · 2012Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Lymphoid organ-resident DC subsets are thought to play unique roles in determining the fate of T cell responses. Recent studies focusing on a single lymphoid organ identified molecular pathways that are differentially operative in each DC subset and led to the assumption that a given DC subset would more or less exhibit the same genomic and functional profiles throughout the body. Whether the local milieu in different anatomical sites can also influence the transcriptome of DC subsets has remained largely unexplored. Here, we interrogated the transcriptional relationships between lymphoid organ-resident DC subsets from spleen, gut- and skin-draining lymph nodes, and thymus of C57BL/6 mice. For this purpose, major resident DC subsets including CD4 and CD8 DCs were sorted at high purity and gene expression profiles were compared using microarray analysis. This investigation revealed that lymphoid organ-resident DC subsets exhibit divergent genomic programs across lymphoid organs. Interestingly, we also found that transcriptional and biochemical properties of a given DC subset can differ between lymphoid organs for lymphoid organ-resident DC subsets, but not plasmacytoid DCs, suggesting that determinants of the tissue milieu program resident DCs for essential site-specific functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.