ArticlePloS one2011
Sex-specific dynamics of global chromatin changes in fetal mouse germ cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Reprogramming the inactive X chromosome: dynamics and insights from the germline.Biochemical Society transactions · 2026Review
- Gonocytes in Transition: Establishing the Male Germline Identity.Advances in experimental medicine and biology · 2026Review
- Locus-resolution analysis of L1 regulation and retrotransposition potential in mouse embryonic development.Genome research · 2023Article
- DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres.EMBO reports · 2023Article
- The remodeling of Z-DNA in the mammalian germ line.Biochemical Society transactions · 2022Article
- Z-DNA is remodelled by ZBTB43 in prospermatogonia to safeguard the germline genome and epigenome.Nature cell biology · 2022Article
- Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation.Molecular psychiatry · 2021Article
- Close Association between Awareness of Teeth-Alignment Disorder and Systemic Disorders in Late Adolescence.Healthcare (Basel, Switzerland) · 2021Article
- Maternal DOT1L is dispensable for mouse development.Scientific reports · 2020Article
- Review
- Large Gender Gap in Oral Hygiene Behavior and Its Impact on Gingival Health in Late Adolescence.International journal of environmental research and public health · 2020Article
- Who's your daddy? Behavioral and epigenetic consequences of paternal drug exposure.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Review
- Transgenerational effects of polychlorinated biphenyls: 1. Development and physiology across 3 generations of rats.Environmental health : a global access science source · 2018Article
- Fetal testis organ culture reproduces the dynamics of epigenetic reprogramming in rat gonocytes.Epigenetics & chromatin · 2017Article
- Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences.Scientific reports · 2016Article
- High histone variant H3.3 content in mouse prospermatogonia suggests a role in epigenetic reformatting.Chromosoma · 2014Article
- Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells.Genes & development · 2014Article
- Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline.Cellular and molecular life sciences : CMLS · 2014Review
- Toward a more precise and informative nomenclature describing fetal and neonatal male germ cells in rodents.Biology of reproduction · 2013Review
- De novo DNA methylation in the male germ line occurs by default but is excluded at sites of H3K4 methylation.Cell reports · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Mammalian germ cells undergo global reprogramming of DNA methylation during their development. Global DNA demethylation occurs around the time when the primordial germ cells colonize the embryonic gonads and this coincides with dynamic changes in chromatin composition. Global de novo DNA methylation takes place with remarkably different dynamics between the two sexes, prospermatogonia attaining methylation during fetal stages and oocytes attaining methylation postnatally. Our hypothesis was that dynamic changes in chromatin composition may precede or accompany the wave of global DNA de novo methylation as well. We used immunocytochemistry to measure global DNA methylation and chromatin components in male and female mouse fetal germ cells compared to control somatic cells of the gonad. We found that global DNA methylation levels sharply increased in male germ cells at 17.5 days post coitum, but remained low in female germ cells at all fetal stages. Global changes in chromatin composition: i, preceded global DNA methylation in fetal germ cells; ii, sex specifically occurred in male but not in female germ cells; iii, affected active and repressive histone marks and iv, included histone tail and histone globular domain modifications. Our data suggest that dynamic changes of chromatin composition may provide a framework for the pattern of male-specific de novo DNA methylation in prospermatogonia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.