ArticleCurrent cancer therapy reviews2011
microRNAs, Gap Junctional Intercellular Communication and Mesenchymal Stem Cells in Breast Cancer Metastasis.
Article in Current cancer therapy reviews, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Pattern of cell-to-cell transfer of microRNA by gap junction and its effect on the proliferation of glioma cells.Cancer science · 2019Article
- MiR-216a exerts tumor-suppressing functions in renal cell carcinoma by targeting TLR4.American journal of cancer research · 2018Article
- Collateral Damage Intended-Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy.International journal of molecular sciences · 2017Review
- Hypothesis of KFrontiers in molecular neuroscience · 2017Review
- Gap junction mediated miRNA intercellular transfer and gene regulation: A novel mechanism for intercellular genetic communication.Scientific reports · 2016Article
- Extracellular vesicles as carriers of microRNA, proteins and lipids in tumor microenvironment.International journal of cancer · 2016Review
- Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development.Scientific reports · 2015Article
- Antitumor effects of TRAIL-expressing mesenchymal stromal cells in a mouse xenograft model of human mesothelioma.Cancer gene therapy · 2015Article
- MicroRNAs and bone metastasis: a new challenge.Molecules (Basel, Switzerland) · 2014Review
- Stem cell delivery of therapies for brain disorders.Clinical and translational medicine · 2014Review
- Article
- Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment.Cell communication and signaling : CCS · 2012Article
- Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations.Journal of cellular biochemistry · 2012Review
- Would cancer stem cells affect the future investment in stem cell therapy.World journal of experimental medicine · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The failed outcome of autologous bone marrow transplantation for breast cancer opens the field for investigations. This is particularly important because the bone marrow could be a major source of cancer cells during tertiary metastasis. This review discusses subsets of breast cancer cells, including those that enter the bone marrow at an early period of disease development, perhaps prior to clinical detection. This population of cells evades chemotherapeutic damage even at high doses. An understanding of this population might be crucial for the success of bone marrow transplants for metastatic breast cancer and for the eradication of cancer cells in bone marrow. In vivo and in vitro studies have demonstrated gap junctional intercellular communication (GJIC) between bone marrow stroma and breast cancer cells. This review discusses GJIC in cancer metastasis, facilitating roles of mesenchymal stem cells (MSCs). In addition, the review addresses potential roles for miRNAs, including those already linked to cancer biology. The literature on MSCs is growing and their links to metastasis are beginning to be significant leads for the development of new drug targets for breast cancer. In summary, this review discusses interactions among GJIC, miRNAs and MSCs as future consideration for the development of cancer therapies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.